Skin biology, xerosis, barrier repair and measurement

Rawlings, A. V., Matts, P. J., Anderson, C. D. and Roberts, M. S. (2008) Skin biology, xerosis, barrier repair and measurement. Drug Discovery Today: Disease Mechanisms, 5 2: e127-e136. doi:10.1016/j.ddmec.2008.03.001


Author Rawlings, A. V.
Matts, P. J.
Anderson, C. D.
Roberts, M. S.
Title Skin biology, xerosis, barrier repair and measurement
Journal name Drug Discovery Today: Disease Mechanisms   Check publisher's open access policy
ISSN 1740-6765
Publication date 2008-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.ddmec.2008.03.001
Open Access Status Not yet assessed
Volume 5
Issue 2
Start page e127
End page e136
Total pages 10
Editor Lowenstein, C.
Place of publication United Kingdom
Publisher Elsevier Ltd., Trends Journals
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
111502 Clinical Pharmacology and Therapeutics
Abstract The skin is a key protective barrier from the environment for terrestrial mammals and is one in a continuous state of renewal and repair. Impairment of skin barrier function is often demonstrated by an altered integrity of the stratum corneum (SC) and a consequential increase in transepidermal water loss (TEWL). Skin barrier function impairment often arises from direct damage followed by a breach in the SC and/or a decrease in or dysfunction of SC lipids. The most common dermatological disorder is dry and flaky skin. This arises from direct damage to the SC with potential mechanical failure and from an impairment in SC cell (corneocyte) maturation and its desquamation together with a decrease in the water holding capacity of the SC. Dry and flaky skin is associated with a range of pathological and physiological abnormalities and can be treated with moisturizers, especially those which enhance SC barrier function. This paper gives a brief overview of the work conducted in this area of science over the past decade.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 01 Apr 2009, 06:15:20 EST by Maree Knight on behalf of School of Medicine