Diffusion modelling of percutaneous absorption kinetics: 4. Effects of a slow equilibration process within stratum corneum on absorption and desorption kinetics

Anissimov, Y. and Roberts, M. S. (2009) Diffusion modelling of percutaneous absorption kinetics: 4. Effects of a slow equilibration process within stratum corneum on absorption and desorption kinetics. Journal of Pharmaceutical Sciences, 98 2: 772-781. doi:10.1002/jps.21461


Author Anissimov, Y.
Roberts, M. S.
Title Diffusion modelling of percutaneous absorption kinetics: 4. Effects of a slow equilibration process within stratum corneum on absorption and desorption kinetics
Journal name Journal of Pharmaceutical Sciences   Check publisher's open access policy
ISSN 0022-3549
Publication date 2009-02-01
Year available 2008
Sub-type Article (original research)
DOI 10.1002/jps.21461
Open Access Status Not yet assessed
Volume 98
Issue 2
Start page 772
End page 781
Total pages 10
Editor Ronald T. Bordchardt
Place of publication United States
Publisher John Wiley & Sons
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
111502 Clinical Pharmacology and Therapeutics
Abstract One of the main functions of the skin is to control the ingress and egress of water into and out of the body. The transport kinetics of water in the stratum corneum (SC), the dominant site of resistance in the skin, is normally described assuming a homogeneous membrane model. In the present work, the desorption of water from SC was studied and profiles obtained for amount desorbed versus time profiles that were more consistent with water transport occurring in a heterogeneous membrane. Analysis of the resulting profiles yields a model that is consistent with a slow equilibration/slow binding of water within SC as well as its permeation through the SC. Diffusion model solutions were used to derive the steady-state flux, lag time and mean desorption time for water in SIC. The slow binding kinetics of water in the SC are limited and most pronounced in the early transient stages of transport and are not easily discerned using steady-state penetration studies. The practical importance of this work is in its use of desorption experiments to recognise and define the skin reservoir for water and other solutes as well as penetration parameters in defining their transdermal kinetics. (C) 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:772-781, 2009
Keyword Percutaneous penetration
Stratum corneum desorption
Slow binding
Skin resevoir effect
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 01 Apr 2009, 02:34:47 EST by Maree Knight on behalf of Medicine - Princess Alexandra Hospital