Gray and white matter changes in Alzheimer's disease: A diffusion tensor imaging study

Rose, Stephen E., Janke, Andrew L. and Chalk, Jonathan B. (2008) Gray and white matter changes in Alzheimer's disease: A diffusion tensor imaging study. Journal of Magnetic Resonance Imaging, 27 1: 20-26. doi:10.1002/jmri.21231


Author Rose, Stephen E.
Janke, Andrew L.
Chalk, Jonathan B.
Title Gray and white matter changes in Alzheimer's disease: A diffusion tensor imaging study
Journal name Journal of Magnetic Resonance Imaging   Check publisher's open access policy
ISSN 1053-1807
Publication date 2008-01-01
Year available 2007
Sub-type Article (original research)
DOI 10.1002/jmri.21231
Open Access Status DOI
Volume 27
Issue 1
Start page 20
End page 26
Total pages 7
Editor C. L. Partin
Place of publication USA
Publisher Willey-Liss
Language eng
Subject C1
110320 Radiology and Organ Imaging
920112 Neurodegenerative Disorders Related to Ageing
1103 Clinical Sciences
1702 Cognitive Sciences
0903 Biomedical Engineering
Abstract Purpose: To investigate microstructural changes in cortical and white matter pathways in patients with Alzheimer's disease using diffusion tensor imaging (DTI).
Formatted abstract
Purpose
To investigate microstructural changes in cortical and white matter pathways in patients with Alzheimer's disease using diffusion tensor imaging (DTI).

Materials and Methods
Measures of mean diffusivity (MD) and fractional anisotropy (FA) were compared in the brains of 13 Alzheimer's disease (AD) patients and a group of 13 aged-matched control participants employing an optimized DTI technique involving a fully automated, voxel-based morphometric (VBM) analysis.

Results
After rigorous control for anatomical variation and confounding partial volume effects, we found significantly elevated MD measures within the hippocampus, amygdala, and medial temporal, parietal, and frontal lobe gray matter regions in the AD participants. The largest number of pixels with increased MD was localized bilaterally, within the posterior cingulate gyrus. The FA was significantly reduced within the thalamus, parietal white matter, and posterior limbs of the internal capsule, indicating significant involvement of corticothalamic and thalamocortical radiations.

Conclusion
This study demonstrates that rigorous VBM analysis of DTI data can be used to investigate microstructural changes in cortical, subcortical, and white matter regions in AD. J. Magn. Reson. Imaging 2007. © 2007 Wiley-Liss, Inc.
Keyword Alzheimer's disease
diffusion tensor imaging
MRI
aging
fractional anisotropy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
ERA 2012 Admin Only
Centre for Advanced Imaging Publications
 
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Created: Wed, 01 Apr 2009, 00:22:31 EST by Lesley-Jayne Jerrard on behalf of Centre For Magnetic Resonance