Productive infection of the bone marrow cells in feline immunodeficiency virus infected cats

Sandy, J. R., Robinson, W. F., Bredhauer, B., Kyaw-Tanner, M. and Howlett, C. R. (2002) Productive infection of the bone marrow cells in feline immunodeficiency virus infected cats. Archives of virology, 147 5: 1053-1059. doi:10.1007/s00705-001-0790-2


Author Sandy, J. R.
Robinson, W. F.
Bredhauer, B.
Kyaw-Tanner, M.
Howlett, C. R.
Title Productive infection of the bone marrow cells in feline immunodeficiency virus infected cats
Journal name Archives of virology   Check publisher's open access policy
ISSN 0304-8608
Publication date 2002-05-01
Sub-type Article (original research)
DOI 10.1007/s00705-001-0790-2
Open Access Status
Volume 147
Issue 5
Start page 1053
End page 1059
Total pages 7
Place of publication Wien
Publisher Springer
Language eng
Subject 0707 Veterinary Sciences
Abstract Bone marrow stromal cells (BMSC) from cats experimentally infected with feline immunodeficiency virus (FIV) were shown to contain FIV provirus using polymerase chain reaction and viral products were detected in culture supernatant using reverse transcriptase and enzyme linked immunosorbent assay techniques. Peripheral blood mononuclear cells from FIV-free cats co-cultured with infected bone marrow cells became productively infected with FIV. Such evidence supports the hypothesis that BMSC are a reservoir for FIV. Furthermore, BMSC produced virions capable of infecting susceptible cells and may represent an important source of infectious virus to cells of the macrophage lineage and/or hemopoietic progenitor cells, both of which ultimately become widely disseminated throughout the body.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Veterinary Science Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 01 Apr 2009, 00:09:52 EST by Ms Lynette Adams on behalf of School of Veterinary Science