Serological prevalence of echinococcosis and risk factors for infection among children in rural communities of southern Ningxia, China

Yang, Yu Rong, Craig, Philip S., Vuitton, Dominique A., Williams, Gail M., Sun, Tao, Liu, Tian Xi, Boufana, Belgees, Giraudoux, Patrick, Teng, Jing, Li, Yanbin, Huang, Ling, Zhang, Wei, Jones, Malcolm K. and McManus, Donald P. (2008) Serological prevalence of echinococcosis and risk factors for infection among children in rural communities of southern Ningxia, China. Tropical Medicine and International Health, 13 8: 1086-1094. doi:10.1111/j.1365-3156.2008.02101.x


Author Yang, Yu Rong
Craig, Philip S.
Vuitton, Dominique A.
Williams, Gail M.
Sun, Tao
Liu, Tian Xi
Boufana, Belgees
Giraudoux, Patrick
Teng, Jing
Li, Yanbin
Huang, Ling
Zhang, Wei
Jones, Malcolm K.
McManus, Donald P.
Title Serological prevalence of echinococcosis and risk factors for infection among children in rural communities of southern Ningxia, China
Journal name Tropical Medicine and International Health   Check publisher's open access policy
ISSN 1360-2276
1365-3156
Publication date 2008-08-01
Year available 2008
Sub-type Article (original research)
DOI 10.1111/j.1365-3156.2008.02101.x
Open Access Status
Volume 13
Issue 8
Start page 1086
End page 1094
Total pages 9
Editor Susanne Groener
Place of publication United Kingdom
Publisher Wiley-Blackwell Publishing Ltd.
Language eng
Subject C1
920109 Infectious Diseases
110803 Medical Parasitology
Abstract OBJECTIVE To assess the usefulness of serology as an indicator of Echinococcus transmission for developing preventive measures against echinococcosis in rural communities.
Formatted abstract
Objective To assess the usefulness of serology as an indicator of Echinococcus transmission for developing preventive measures against echinococcosis in rural communities.

Methods
Cross-sectional survey in 2002 among 861 children aged 7 to 18 years in Xiji County, Ningxia, China. Before ultrasound abdominal examination, a questionnaire was used to identify socioeconomic, sanitary and hygiene risk factors for echinococcal infection; filter paper blood samples were collected from each child for specific antibody detection using EmP (Echinococcus multilocularis) and EgB (Echinococcus granulosus) antigens.

Results Transmission of both E. multilocularis and E. granulosus occur in this area. Serological prevalence was far higher than disease prevalence in this age range. We found no gender-related differences of seroprevalence among the children, suggesting an equal chance of exposure to echinococcal egg-contaminated environments. The seroprevalence distribution was associated with changes in the ecology of wild hosts for E. multilocularis contamination, and with changes in socio-geographic features of the communities for E. granulosus contamination.

Conclusions Serological data obtained for children in mass surveys of echinococcosis appear to be a comprehensive and useful tool to monitor changes of transmission dynamics in humans and provide 'warning signals' to decision makers for the instigation of specific control measures against the disease.
Keyword children seroprevalence
EmP antigen
EgB antigen
filter-paper enzyme-linked immunosorbent assay
human alveolar and cystic echinococcosis
risk factors for infection
Ningxia Hui Autonomous Region
China
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Public Health Publications
 
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Created: Tue, 31 Mar 2009, 20:33:32 EST by Geraldine Fitzgerald on behalf of School of Public Health