Gastritis Associated with Helicobacter-like Organisms in Baboons

Mackie, J. T. and O'Rourke, J. L. (2003) Gastritis Associated with Helicobacter-like Organisms in Baboons. Veterinary Pathology, 40 5: 563-566. doi:10.1354/vp.40-5-563

Author Mackie, J. T.
O'Rourke, J. L.
Title Gastritis Associated with Helicobacter-like Organisms in Baboons
Journal name Veterinary Pathology   Check publisher's open access policy
ISSN 0300-9858
Publication date 2003-09-01
Sub-type Article (original research)
DOI 10.1354/vp.40-5-563
Open Access Status Not Open Access
Volume 40
Issue 5
Start page 563
End page 566
Total pages 4
Place of publication Lawrence, Kansas
Publisher American College of Veterinary Pathologists
Language eng
Subject 070709 Veterinary Pathology
Abstract Subclinical gastritis was observed in 10 of 10 baboons (Papio spp.) from a toxicity study in a research facility. The lesions were similar in xenobiotic-treated and control animals, suggesting a spontaneous rather than chemical-induced disease. Histologic examination revealed lymphoplasmacytic gastritis in the antral mucosa. The fundic mucosa contained minor, scattered aggregates of lymphocytes and plasma cells. A Warthin-Starry silver stain and ultrastructural examination revealed numerous spiral-shaped bacteria morphologically resembling Helicobacter pylori in antral glands and numerous spiral-shaped bacteria morphologically consistent with H. heilmannii–like organisms in fundic glands. Polymerase chain reaction assay of paraffin-embedded antral and fundic tissue using primers for the urease gene and 16S ribosomal ribonucleic acid gene amplified deoxyribonucleic acid fragments with a high degree of sequence homology for H. pylori and H. heilmannii. This is the first report of gastritis associated with Helicobacter-like organisms in baboons.
Keyword Veterinary pathology
Helicobacter heilmannii
Helicobacter pylori
nonhuman primates
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Veterinary Science Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 31 Mar 2009, 20:15:54 EST by Ms Karen Naughton on behalf of School of Veterinary Science