Physical Activity and Risk of Endometrial Cancer: The European Prospective Investigation into Cancer and Nutrition

Friedenreich, Christine, Cust, Anne, Lahmann, Petra H., Steindorf, Karen, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Mesrine, Sylvie, Linseisen, Jakob, Rohrmann, Sabine, Tobias, Pischon, Schulz, Mandy, Tjønneland, Anne, Johnsen, Nina Fons, Overvad, Kim, Mendez, Michelle, Arguelles, M.V., Garcia, Carmen Martinez, Larrañaga, Nerea, Chirlaque, María-Dolores, Ardanaz, Eva, Bingham, Sheila, Khaw, Kay-Tee, Allen, Naomi, Key, Tim, Trichopoulou, Antonia, Dilis, Vardis, Trichopoulos, Dimitrios, Pala, Valeria, Palli, Domenico, Tumino, Rosario, Panico, Salvatore, Vineis, Paolo, Bueno-de-Mesquita, H. Bas, Peeters, Petra H.M., Monninkhof, Evelyn, Berglund, Göran, Manjer, Jonas, Slimani, Nadia, Ferrari, Pietro, Kaaks, Rudolf, Riboli, Kaaks and Riboli, Elio (2007) Physical Activity and Risk of Endometrial Cancer: The European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 121 2: 347-355. doi:10.1002/ijc.22676

Author Friedenreich, Christine
Cust, Anne
Lahmann, Petra H.
Steindorf, Karen
Boutron-Ruault, Marie-Christine
Clavel-Chapelon, Françoise
Mesrine, Sylvie
Linseisen, Jakob
Rohrmann, Sabine
Tobias, Pischon
Schulz, Mandy
Tjønneland, Anne
Johnsen, Nina Fons
Overvad, Kim
Mendez, Michelle
Arguelles, M.V.
Garcia, Carmen Martinez
Larrañaga, Nerea
Chirlaque, María-Dolores
Ardanaz, Eva
Bingham, Sheila
Khaw, Kay-Tee
Allen, Naomi
Key, Tim
Trichopoulou, Antonia
Dilis, Vardis
Trichopoulos, Dimitrios
Pala, Valeria
Palli, Domenico
Tumino, Rosario
Panico, Salvatore
Vineis, Paolo
Bueno-de-Mesquita, H. Bas
Peeters, Petra H.M.
Monninkhof, Evelyn
Berglund, Göran
Manjer, Jonas
Slimani, Nadia
Ferrari, Pietro
Kaaks, Rudolf
Riboli, Kaaks
Riboli, Elio
Title Physical Activity and Risk of Endometrial Cancer: The European Prospective Investigation into Cancer and Nutrition
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 1097-0215
Publication date 2007-07-15
Sub-type Article (original research)
DOI 10.1002/ijc.22676
Open Access Status
Volume 121
Issue 2
Start page 347
End page 355
Total pages 9
Place of publication New York, N.Y.
Publisher Wiley-Liss
Language eng
Subject 1117 Public Health and Health Services
Abstract The etiologic role of physical activity in endometrial cancer risk remains unclear given the few epidemiologic studies that have been conducted. To investigate this relation more fully, an analysis was undertaken in the European prospective investigation into cancer and nutrition (EPIC). During an average 6.6 years of follow-up, 689 incident endometrial cancer cases were identified from an analytic cohort within EPIC of 253,023 women. Cox proportional hazards models were used to estimate the associations between type of activity (total, occupational, household, recreational) and endometrial cancer risk. For total activity, women in the highest compared with the lowest quartile of activity had a risk of 0.88 (95% confidence interval (95% CI = 0.61-1.27). No clear associations between each type of activity and endometrial cancer risk were found for the total study population combined. Associations were more evident in the stratified results, with premenopausal women who were active versus inactive experiencing a risk of 0.66 (95% CI = 0.38-1.14) overall. Among premenopausal women, for household and recreational activities the risk estimates in the highest as compared with the lowest quartiles were, respectively, 0.48 (95% CI = 0.23-0.99) and 0.78 (95% CI = 0.44-1.39). No effect modification by body mass index, hormone replacement therapy, oral contraceptive use or energy intake was found. This study provides no evidence of a protective effect of increased physical activity in endometrial cancer risk in all women but some support for a benefit among premenopausal women. The relative risk reductions are most apparent for household activities. © 2007 Wiley-Liss, Inc.
Keyword Physical activity
Endometrial cancer
Biologic mechanisms
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
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Created: Tue, 31 Mar 2009, 20:06:50 EST by Juliette Grosvenor on behalf of School of Public Health