Increased levels of activated T-cells and reduced levels of CD4/CD25+ cells in peripheral blood of Guillain-Barre syndrome patients compared to controls

Harness, J. and McCombe, Pamela A. (2008) Increased levels of activated T-cells and reduced levels of CD4/CD25+ cells in peripheral blood of Guillain-Barre syndrome patients compared to controls. Journal of Clinical Neuroscience, 15 9: 1031--1035. doi:10.1016/j.jocn.2007.09.016


Author Harness, J.
McCombe, Pamela A.
Title Increased levels of activated T-cells and reduced levels of CD4/CD25+ cells in peripheral blood of Guillain-Barre syndrome patients compared to controls
Journal name Journal of Clinical Neuroscience   Check publisher's open access policy
ISSN 0967-5868
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.jocn.2007.09.016
Open Access Status DOI
Volume 15
Issue 9
Start page 1031-
End page 1035
Total pages 5
Editor Kaye, A.H.
Place of publication Edinburgh U.K.
Publisher Churchill Livingstone
Language eng
Subject C1
110904 Neurology and Neuromuscular Diseases
920111 Nervous System and Disorders
Abstract Guillain-Barre syndrome (GBS) is a severe, self-limiting, autoimmune motor neuropathy. This study was performed to investigate the numbers of activated T-cells and regulatory T-cells, and CD95 and bcl-2 expression in GBS patients compared to controls. The percentage of cells expressing CD69 (activated T-cells) was increased in the blood of both patients with GBS and those with other neuropathies compared to healthy controls. GBS patients displayed significant decreases in the percentage of T-lymphocytes (CD3) and CD4/CD25+ cells (T regulatory cells) compared to patients with other neuropathies and a reduction in the percentage of cytotoxic/suppressor T-lymphocytes (CD8) compared to healthy controls. CD95 expression was reduced in GBS compared to patients with other neuropathies and expression of Bcl-2 was increased in GBS compared to healthy controls. We therefore suggest that in GBS there are increased activated T-cells and disturbances in regulatory T-cells and T-cell apoptosis. (C) 2007 Elsevier Ltd. All rights reserved.
Keyword Clinical Neurology
Neurosciences
Neurosciences & Neurology
CLINICAL NEUROLOGY
NEUROSCIENCES
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
UQ Centre for Clinical Research Publications
 
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Created: Tue, 31 Mar 2009, 01:52:13 EST by Carmen Buttery on behalf of UQ Centre for Clinical Research