Immune and inflammatory responses to stroke: Good or bad?

McCombe, Pamela A. and Read, Stephen J. (2008) Immune and inflammatory responses to stroke: Good or bad?. International Journal of Stroke, 3 4: 254-265. doi:10.1111/j.1747-4949.2008.00222.x


Author McCombe, Pamela A.
Read, Stephen J.
Title Immune and inflammatory responses to stroke: Good or bad?
Journal name International Journal of Stroke   Check publisher's open access policy
ISSN 1747-4930
1747-4949
Publication date 2008-11-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1747-4949.2008.00222.x
Open Access Status DOI
Volume 3
Issue 4
Start page 254
End page 265
Total pages 12
Place of publication Richmond, Vic., Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Subject C1
110904 Neurology and Neuromuscular Diseases
920111 Nervous System and Disorders
Abstract Inflammatory and immune responses play important roles following ischaemic stroke. Inflammatory responses contribute to damage and also contribute to repair. Injury to tissue triggers an immune response. This is initiated through activation of the innate immune system. In stroke there is microglial activation. This is followed by an influx of lymphocytes and macrophages into the brain, triggered by production of pro-inflammatory cytokines. This inflammatory response contributes to further tissue injury. There is also a systemic immune response to stroke, and there is a degree of immunosuppression that may contribute to the stroke patient's risk of infection. This immunosuppressive response may also be protective, with regulatory lymphocytes producing cytokines and growth factors that are neuroprotective. The specific targets of the immune response after stroke are not known, and the details of the immune and inflammatory responses are only partly understood. The role of inflammation and immune responses after stroke is twofold. The immune system may contribute to damage after stroke, but may also contribute to repair processes. The possibility that some of the immune response after stroke may be neuroprotective is exciting and suggests that deliberate enhancement of these responses may be a therapeutic option.
Keyword Immune response
Inflammation
Microglia
Protective immunity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
UQ Centre for Clinical Research Publications
 
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Created: Tue, 31 Mar 2009, 01:38:35 EST by Carmen Buttery on behalf of UQ Centre for Clinical Research