Non-melanoma skin cancers

Ahmed, A. H., Soyer, H. P., Saunders, N., Boukamp, P. and Roberts, M. S. (2008) Non-melanoma skin cancers. Drug Discovery Today: Disease Mechanisms, 5 1: e55-e62. doi:10.1016/j.ddmec.2008.05.007


Author Ahmed, A. H.
Soyer, H. P.
Saunders, N.
Boukamp, P.
Roberts, M. S.
Title Non-melanoma skin cancers
Journal name Drug Discovery Today: Disease Mechanisms   Check publisher's open access policy
ISSN 1740-6765
Publication date 2008-01-01
Sub-type Article (original research)
DOI 10.1016/j.ddmec.2008.05.007
Open Access Status Not yet assessed
Volume 5
Issue 1
Start page e55
End page e62
Total pages 8
Editor Lowenstein, C.
Place of publication United Kingdom
Publisher Elsevier Ltd, Trends Journals
Language eng
Subject C1
920117 Skin and Related Disorders
111201 Cancer Cell Biology
Abstract This review examines the nature, incidence and molecular pathogenesis associated with non-melanoma skin cancers (NMSC). These comprise the basal cell carcinomas (BCCs), the most frequent though rarely metastasizing skin tumours, the more aggressive squamous cell carcinomas (SCCs), which are a problem especially in immunosuppressed organ transplant recipients. UV radiation is a key risk factor for both BSC and SCC. Whereas BCCs are associated with a limited number of sunburns (may be a one or more severe sunburns), SCCs usually occur after with recurrent UV exposure - with sun damage induced actinic keratoses as a well-established precursor. Each carcinoma may be associated with several chromosomal mutations and prevention is preferred to treatment, of which surgery is the first choice.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Tue, 31 Mar 2009, 01:33:55 EST by Maree Knight on behalf of School of Medicine