Autoantibody-mediated bowel and bladder dysfunction in a patient with chronic, nondiabetic neuropathy

Jackson, Michael W., Gordon, Thomas P. and McCombe, Pamela A. (2008) Autoantibody-mediated bowel and bladder dysfunction in a patient with chronic, nondiabetic neuropathy. Muscle and Nerve, 37 4: 537-543. doi:10.1002/mus.20946


Author Jackson, Michael W.
Gordon, Thomas P.
McCombe, Pamela A.
Title Autoantibody-mediated bowel and bladder dysfunction in a patient with chronic, nondiabetic neuropathy
Journal name Muscle and Nerve   Check publisher's open access policy
ISSN 1097-4598
0148-639X
Publication date 2008-04-01
Year available 2007
Sub-type Article (original research)
DOI 10.1002/mus.20946
Open Access Status Not yet assessed
Volume 37
Issue 4
Start page 537
End page 543
Total pages 7
Editor M.J. Aminoff
Place of publication Hoboken, New Jersey, USA
Publisher John Wiley & Sons
Language eng
Subject 110904 Neurology and Neuromuscular Diseases
920111 Nervous System and Disorders
CX
Abstract Physiological techniques can be used to detect novel autoantibodies causing alteration of autonomic function after passive transfer to mice. Previously, such antibodies have been detected in patients with type I diabetes mellitus, myasthenia gravis, and Sjogren's syndrome. We now describe a patient with an idiopathic nondiabetic neuropathy with prominent autonomic symptoms, including bladder and bowel dysfunction. Physiological assays of whole colon and bladder were used to determine the presence in the patient serum of functional autoantibodies capable of mediating autonomic dysfunction. Immunoglobulin G (IgG) from this patient was able to disrupt bladder and bowel function on passive transfer to mice. This is a new pattern of autoantibody-mediated abnormality. Although the target antigen is unknown, it is likely to be a cell-surface receptor or ion channel. This case highlights the usefulness of passive transfer studies in detecting functional antibodies in patients with autonomic neuropathy. Muscle Nerve, 2007
Keyword antibody
autonomic neuropathy
neuropathy
passive transfer
physiology
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published Online: 5 Dec 2007

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Tue, 31 Mar 2009, 01:32:18 EST by Carmen Buttery on behalf of UQ Centre for Clinical Research