Defective responses to DNA single- and double-strand breaks in spinocerebellar ataxia

Lavin, Martin F., Nuri Gueven and Grattan-Smith, P. (2008) Defective responses to DNA single- and double-strand breaks in spinocerebellar ataxia. Dna Repair, 7 7: 1061-1076. doi:10.1016/j.dnarep.2008.03.008


Author Lavin, Martin F.
Nuri Gueven
Grattan-Smith, P.
Title Defective responses to DNA single- and double-strand breaks in spinocerebellar ataxia
Journal name Dna Repair   Check publisher's open access policy
ISSN 1568-7864
Publication date 2008-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.dnarep.2008.03.008
Open Access Status Not yet assessed
Volume 7
Issue 7
Start page 1061
End page 1076
Total pages 16
Editor Friedberg, E.C.
Place of publication Amsterdam
Publisher Elseiver BV
Language eng
Subject C1
920111 Nervous System and Disorders
110902 Cellular Nervous System
Abstract Failure to maintain the integrity of DNA/chromatin can result in genome instability and an increased risk of cancer. The description of a number of human genetic disorders characterised not only by cancer predisposition but by a broader phenotype including neurodegeneration suggests that maintaining genome stability is also important for preserving post-mitotic neurons. The identification of genes associated with other neurodegenerative disorders provides further evidence for the importance of DNA damage response and DNA repair genes in protecting against neurodegeneration. This theme is further developed in this review.
Keyword DNA damage response
Genome instability
Neurodegeneration
Spinocerebellar ataxia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
UQ Centre for Clinical Research Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 16 times in Scopus Article | Citations
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Created: Tue, 31 Mar 2009, 00:27:47 EST by Carmen Buttery on behalf of UQ Centre for Clinical Research