GABAᴀ receptors containing gamma 1 subunits contribute to inhibitory transmission in the central amygdala

Esmaeili, Abolghasem, Lynch, Joseph W. and Sah, Pankaj (2009) GABAᴀ receptors containing gamma 1 subunits contribute to inhibitory transmission in the central amygdala. Journal of Neurophysiology, 101 1: 341-349. doi:10.1152/jn.90991.2008


Author Esmaeili, Abolghasem
Lynch, Joseph W.
Sah, Pankaj
Title GABAᴀ receptors containing gamma 1 subunits contribute to inhibitory transmission in the central amygdala
Formatted title
GABAᴀ Receptors Containing Gamma 1 Subunits Contribute to Inhibitory Transmission in the Central Amygdala
Journal name Journal of Neurophysiology   Check publisher's open access policy
ISSN 0022-3077
1522-1598
Publication date 2009-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1152/jn.90991.2008
Volume 101
Issue 1
Start page 341
End page 349
Total pages 9
Editor Brenda B. Rauner
D. Linden
Eve Marder
Place of publication United States
Publisher American Physiological Society
Collection year 2009
Language eng
Subject C1
110903 Central Nervous System
920111 Nervous System and Disorders
110902 Cellular Nervous System
060601 Animal Physiology - Biophysics
Abstract Esmaeili A, Lynch JW, Sah P. GABA(A) receptors containing gamma1 subunits contribute to inhibitory transmission in the central amygdale. J Neurophysiol 101: 341-349, 2009. First published November 12, 2008; doi:10.1152/jn.90991.2008. gamma-Aminobutyric acid ( GABA(A)) is the primary inhibitory transmitter in the mammalian brain. This inhibition is mediated by type A (GABA(A)) receptors that are pentameric proteins assembled from 14 different subunits. Although inhibitory synaptic transmission has been studied in the amygdala, the subunit composition of receptors present at different synapses is not well understood. In this study we examined the subunit composition of GABA(A) receptors at synapses in the basolateral and central amygdala. Using receptors expressed in HEK293 cells we first determined the pharmacology of receptors of different subunit compositions. We then used this pharmacological profile to test the properties of receptors present at synapses in the central and basolateral amygdala. These results show that the GABA(A) receptor subunits are differentially distributed in the amygdala. Our data indicate that in the basolateral amygdala, GABAergic synapses are likely composed of receptors that contain alpha 2 beta x gamma 2 subunits. In the central amygdala receptors at the medial input, carrying afferents from the bed nucleus of the stria terminalis contain similar receptors, whereas in the lateral input GABA(A) receptors likely contain gamma 1 subunits. These inputs arise from the intercalated cells masses, thought to be responsible for mediating extinction of conditioned fear, raising the possibility of new targets for the treatment of anxiety-related disorders.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Queensland Brain Institute Publications
School of Biomedical Sciences Publications
 
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Created: Mon, 30 Mar 2009, 22:05:45 EST by Debra McMurtrie on behalf of Queensland Brain Institute