Combining chemistry and biology to create colloidally stable bionanohydroxyapatite particles: Toward load-bearing bone applications

Rai, B., Grondahl, L. and Trau, M. (2008) Combining chemistry and biology to create colloidally stable bionanohydroxyapatite particles: Toward load-bearing bone applications. Langmuir, 24 15: 7744-7749. doi:10.1021/la8005212


Author Rai, B.
Grondahl, L.
Trau, M.
Title Combining chemistry and biology to create colloidally stable bionanohydroxyapatite particles: Toward load-bearing bone applications
Journal name Langmuir   Check publisher's open access policy
ISSN 0743-7463
Publication date 2008-06-21
Year available 2008
Sub-type Article (original research)
DOI 10.1021/la8005212
Open Access Status Not yet assessed
Volume 24
Issue 15
Start page 7744
End page 7749
Total pages 6
Place of publication United States
Publisher American Chemical Society
Language eng
Subject C1
030603 Colloid and Surface Chemistry
920116 Skeletal System and Disorders (incl. Arthritis)
Abstract This study presents a layer by layer assembly on nanohydroxyapatite (nHA) particles with the dual aim of enhancing particle dispersion and biological response to produce superior reinforcements intended for load-bearing applications. The system tested consists of three sequential biological polyelectrolyte layers of heparin (representing glycosaminoglycans), polyhistidine (representing growth factors), and heparin adsorbed onto nHA. The results reveal that the resulting bio-nHA particles with an outer heparin layer are colloidally stable in aqueous solution for 23 days. Adsorption isotherms combined with Ca2+ release studies allowed a detailed description of each adsorbed layer. Release patterns for each adsorbed layer reveal that the biological polyelectrolytes are, at least in part, released as polyelectrolyte complexes. In conclusion, the combination of its colloidal dispersant properties and osteoinductive potential make the developed bio-nHA particles promising reinforcements to improve current composite biomaterials or bone-engineering scaffolds toward load-bearing dental and orthopedic applications.
Keyword Chemistry, Multidisciplinary
Chemistry, Physical
Materials Science, Multidisciplinary
Chemistry
Materials Science
CHEMISTRY, MULTIDISCIPLINARY
CHEMISTRY, PHYSICAL
MATERIALS SCIENCE, MULTIDISCIPLINARY
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 13 times in Scopus Article | Citations
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Created: Mon, 30 Mar 2009, 22:01:02 EST by Glenda Chown on behalf of School of Chemistry & Molecular Biosciences