Selective Losses of Brainstem Catecholamine Neurons After Hypoxia-Ischemia in the Immature Rat Pup.

Buller, Kathryn M., Julie Wixey, Pathipati, Praneeti, Michelle Carty, Colditz, Paul B., Williams, Christopher E. and Scheepens, Arjan (2008) Selective Losses of Brainstem Catecholamine Neurons After Hypoxia-Ischemia in the Immature Rat Pup.. Pediatric Research, 63 4: 364-369. doi:10.1203/PDR.0b013e3181659774


Author Buller, Kathryn M.
Julie Wixey
Pathipati, Praneeti
Michelle Carty
Colditz, Paul B.
Williams, Christopher E.
Scheepens, Arjan
Title Selective Losses of Brainstem Catecholamine Neurons After Hypoxia-Ischemia in the Immature Rat Pup.
Journal name Pediatric Research   Check publisher's open access policy
ISSN 0031-3998
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1203/PDR.0b013e3181659774
Open Access Status
Volume 63
Issue 4
Start page 364
End page 369
Total pages 5
Editor Devaskar, Sherin U.
Place of publication United States
Publisher Lippincott Williams & Wilkins
Language eng
Subject C1
929999 Health not elsewhere classified
060105 Cell Neurochemistry
Abstract Hypoxic-ischemic (HI) injury in the preterm neonate incurs numerous functional deficits, however little is known about the neurochemically-defined brain nuclei that may underpin them. Key candidates are the brainstem catecholamine neurons. Using an immature animal model, the postnatal day (P)-3 (P3) rat pup, we investigated the effects of HI on brainstem catecholamine neurons in the locus coeruleus, nucleus tractus solitarius (NTS), and ventrolateral medulla (VLM). On P21, we found that prior P3 HI significantly reduced numbers of catecholaminergic neurons in the locus coeruleus, NTS, and VLM. Only locus coeruleus A6, NTS A2, and VLM A1 noradrenergic neurons, but not NTS C2 and VLM C1 adrenergic neurons, were lost. There was also an associated reduction in dopamine-beta-hydroxylase-positive immunolabeling in the forebrain. These findings suggest neonatal HI can affect specific neurochemically-defined neuronal populations in the brainstem and that noradrenergic neurons are particularly vulnerable to HI injury.
Keyword Pediatrics
Pediatrics
PEDIATRICS
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
UQ Centre for Clinical Research Publications
 
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Created: Mon, 30 Mar 2009, 01:01:20 EST by Amanda Barnett on behalf of UQ Centre for Clinical Research