Associations between serum cortisol, cardiovascular function and neurological outcome following acute global hypoxia in the newborn piglet

Harris, Thomas A., Healy, Genevieve N., Colditz, Paul B. and Lingwood, Barbara E. (2009) Associations between serum cortisol, cardiovascular function and neurological outcome following acute global hypoxia in the newborn piglet. Stress: The International Journal on the Biology of Stress, 12 4: 294-304. doi:10.1080/10253890802372414


Author Harris, Thomas A.
Healy, Genevieve N.
Colditz, Paul B.
Lingwood, Barbara E.
Title Associations between serum cortisol, cardiovascular function and neurological outcome following acute global hypoxia in the newborn piglet
Journal name Stress: The International Journal on the Biology of Stress   Check publisher's open access policy
ISSN 1025-3890
1607-8888
Publication date 2009-07-01
Year available 2009
Sub-type Article (original research)
DOI 10.1080/10253890802372414
Open Access Status Not yet assessed
Volume 12
Issue 4
Start page 294
End page 304
Total pages 11
Editor John A. Russell
Place of publication Abingdon, U.K.
Publisher Taylor & Francis, Inc.
Language eng
Subject C1
920103 Cardiovascular System and Diseases
110201 Cardiology (incl. Cardiovascular Diseases)
111401 Foetal Development and Medicine
920501 Child Health
Abstract Perinatal asphyxia is a significant contributor to neonatal brain injury. However, there is significant variability in neurological outcome in neonates after global hypoxia-ischemia. The aims of this study were to identify which physiological response/s during global hypoxia-ischemia influence the severity of brain injury and to assess their relative importance. Hypoxia/hypercapnia was induced in 20 anaesthetized piglets by reducing the inspired oxygen fraction to 10% and the ventilation rate from 30 to 10 breaths per minute for 45 min. Neurological outcome was assessed using functional markers including cerebral function amplitude (via electroencephalography) and cerebral impedance, and the structural marker microtubule associated protein-2 by immunohistochemistry at 6 h post hypoxia. Significant variability in neurological outcome was observed following the constant hypoxia/hypercapnia insult. There was a high degree of variability in cardiovascular function (mean arterial blood pressure and heart rate) and serum cortisol concentrations in response to hypoxia. More effective maintenance of cardiovascular function and higher serum cortisol concentrations were associated with a better outcome. These two variables were strongly associated with neurological outcome, and together explained 68% of the variation in the severity of neurological outcome. The variability in the cardiovascular and cortisol responses to hypoxia may be a more important determinant of neurological outcome then previously recognized.
Keyword Cortisol
Cardiovascular function
Hypoxia
Neonatal piglet
Neurological outcome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
UQ Centre for Clinical Research Publications
School of Public Health Publications
 
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Created: Sun, 29 Mar 2009, 23:53:40 EST by Amanda Barnett on behalf of UQ Centre for Clinical Research