Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans

Doi, Y., Poirel, L., Nordmann,P. and David Paterson (2008) Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans. Antimicrobial Agents and Chemotherapy, 52 52: 1952-1956. doi:10.1128/AAC.01463-07

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Author Doi, Y.
Poirel, L.
Nordmann,P.
David Paterson
Title Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans
Journal name Antimicrobial Agents and Chemotherapy   Check publisher's open access policy
ISSN 0066-4804
ISBN 6
Publication date 2008-06-01
Year available 2008
Sub-type Article (original research)
DOI 10.1128/AAC.01463-07
Open Access Status File (Publisher version)
Volume 52
Issue 52
Start page 1952
End page 1956
Total pages 5
Editor George M. Eliopoulos
Place of publication Washington, DC, United States
Publisher American Society for Microbioloby
Language eng
Subject C1
110309 Infectious Diseases
920109 Infectious Diseases
Abstract A chromosomally encoded class D beta-lactamase, OXA-114, was characterized from Achromobacter xylosoxidans strain CIP69598. beta-Lactamase OXA-114 shared 56% amino acid identity with the naturally occurring class D beta-lactamase of Burkholderia cenocepacia and 42% identity with the acquired oxacillinases OXA-9 and OXA-18. OXA-114 has a narrow-spectrum hydrolysis profile, although it includes imipenem, at a very low level. PCR and sequencing revealed that bla(OXA114)-like genes were identified in all A. xylosoxidans strains tested (n = 5), indicating that this beta-lactamase is naturally occurring in that species. Induction experiments with imipenem and cefoxitin did not show inducibility of bla(OXA)-114 expression.
Keyword Microbiology
Pharmacology & Pharmacy
Microbiology
Pharmacology & Pharmacy
MICROBIOLOGY
PHARMACOLOGY & PHARMACY
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID T32 AI007333
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
UQ Centre for Clinical Research Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 29 Mar 2009, 20:37:28 EST by Carmen Buttery on behalf of UQ Centre for Clinical Research