Assessment of the potency and potential immunomodulatory effects of the measles mumps rubella and varicella vaccine in infants

YerkovichST, RoweJ, RichmondP, SuriyaarachchiD, HeatonT, HollamsE, LadymanC, SerralhaM, SadowskaA, LohR, WesselinghSL, Sly, P. D. and HoltPG (2007) Assessment of the potency and potential immunomodulatory effects of the measles mumps rubella and varicella vaccine in infants. Vaccine, 25 10: 1764-1770. doi:10.1016/j.vaccine.2006.11.022


Author YerkovichST
RoweJ
RichmondP
SuriyaarachchiD
HeatonT
HollamsE
LadymanC
SerralhaM
SadowskaA
LohR
WesselinghSL
Sly, P. D.
HoltPG
Title Assessment of the potency and potential immunomodulatory effects of the measles mumps rubella and varicella vaccine in infants
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-110X
0264-410X
Publication date 2007-02-01
Year available 2007
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2006.11.022
Open Access Status Not yet assessed
Volume 25
Issue 10
Start page 1764
End page 1770
Total pages 7
Place of publication Oxford
Publisher Elsevier
Language eng
Subject 110704 Cellular Immunology
Abstract This study compared the potency and immunomodulatory effects of measles mumps rubella (MMR) vaccine given to infants alone or in combination with varicella (MMR and V). In an additional group,MMRvaccination was delayed 42 days to permit analysis of potential effects on underlying maturation of systemic immune functions. Assessment of immunity to the vaccines indicated consistent antibody production coupled with mixed Th1/Th2 memory, and no significant differences between vaccine groups or to the group who had their MMR vaccination delayed. Parallel analyses of cytokine responses to phytohaemagglutinin and tetanus toxoid did not detect any “bystander” effects of the vaccines on systemic immunity. © 2006 Elsevier Ltd. All rights reserved.
Keyword Immunology
Medicine, Research & Experimental
Immunology
Research & Experimental Medicine
IMMUNOLOGY
MEDICINE, RESEARCH & EXPERIMENTAL
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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Created: Sat, 28 Mar 2009, 02:16:10 EST by Paul Rollo on behalf of Medicine - Princess Alexandra Hospital