The role of hypertonic saline in neurotrauma

White, H., Cook, D. and Venkatesh, B. (2008) The role of hypertonic saline in neurotrauma. European Journal of Anaesthesiology, 25 Supp. 42: 104-109. doi:10.1017/S0265021507003420

Author White, H.
Cook, D.
Venkatesh, B.
Title The role of hypertonic saline in neurotrauma
Journal name European Journal of Anaesthesiology   Check publisher's open access policy
ISSN 0265-0215
Publication date 2008-01-01
Sub-type Article (original research)
DOI 10.1017/S0265021507003420
Open Access Status
Volume 25
Issue Supp. 42
Start page 104
End page 109
Total pages 6
Place of publication Philadelphia, PA, U.S.A.
Publisher Lippincott Williams & Wilkins
Language eng
Subject C1
920111 Nervous System and Disorders
110310 Intensive Care
Abstract Animal and human studies suggest that hypertonic saline is a potential therapeutic agent to assist with the medical treatment of patients with traumatic brain injury. It may have a place as osmotherapy to decrease brain size, predominately of uninjured brain and has several potential advantages over mannitol. Hypertonic saline has clinically desirable physiological effects on cerebral blood flow, intracranial pressure and inflammatory responses in models of neurotrauma. Animal studies support its use, but definitive human trials using mortality end-points in brain trauma are lacking. Hypertonic saline may be considered a therapeutic adjunct to the medical management of traumatic brain injury, awaiting definitive evidence to support routine use.
Keyword Saline solution hypertonic
Intracranial pressure
Intracranial hypertension
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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Created: Sat, 28 Mar 2009, 01:02:40 EST by Denise Wilson on behalf of School of Medicine