Randomized controlled trial of nutritional counseling on body composition and dietary intake in severe CKD

Campbell, Katrina L., Ash, Susan, Davies, Peter S. W. and Bauer, Judith D. (2008) Randomized controlled trial of nutritional counseling on body composition and dietary intake in severe CKD. American Journal of Kidney Diseases, 51 5: 748-758. doi:10.1053/j.ajkd.2007.12.015


Author Campbell, Katrina L.
Ash, Susan
Davies, Peter S. W.
Bauer, Judith D.
Title Randomized controlled trial of nutritional counseling on body composition and dietary intake in severe CKD
Journal name American Journal of Kidney Diseases   Check publisher's open access policy
ISSN 0272-6386
Publication date 2008-05-01
Year available 2008
Sub-type Article (original research)
DOI 10.1053/j.ajkd.2007.12.015
Open Access Status DOI
Volume 51
Issue 5
Start page 748
End page 758
Total pages 11
Editor Bertran L. Kasiske
Place of publication New York, N.Y, United States
Publisher Elsevier
Language eng
Subject C1
110312 Nephrology and Urology
920411 Nutrition
11 Medical and Health Sciences
1111 Nutrition and Dietetics
Abstract Background: Progressive loss of kidney function results in an increased risk of malnutrition. Despite this, there is little evidence informing the impact of nutrition intervention on predialysis patients with chronic kidney disease (CKD; stages 4 and 5).
Formatted abstract
BACKGROUND:
Progressive loss of kidney function results in an increased risk of malnutrition. Despite this, there is little evidence informing the impact of nutrition intervention on predialysis patients with chronic kidney disease (CKD; stages 4 and 5).

STUDY DESIGN:
Randomized controlled trial.

SETTING & PARTICIPANTS:

56 outpatients (men, 62%; mean age, 70.7 +/- 14.0 [SD] years) with CKD were randomly allocated to intervention (n = 29) or control (n = 27) by using a concealed computer-generated sequence.

INTERVENTION:

The intervention group, provided with individualized dietary counseling with regular follow-up aimed at achieving an intake of 0.8 to 1.0 g/kg of protein and greater than 125 kJ/kg of energy, or control, receiving written material only.

OUTCOMES & MEASURES:
Change in body composition (body cell mass, measured by means of total-body potassium, in 40 of 56 participants), nutritional status (Subjective Global Assessment), and energy and protein intake (3-day food record).

RESULTS:
During the 12 weeks, the intervention group had 3.5% (95% confidence interval, -2.1 to 9.1) less decrease in body cell mass, 17.7-kJ/kg/d (95% confidence interval, 8.2 to 27.2) greater increase in energy intake, greater improvement in Subjective Global Assessment (P < 0.01), and no significant difference in protein intake compared with the control group (-0.04 g/kg/d; 95% confidence interval, -0.73 to 0.16). The intervention was associated with greater increases in energy and protein intake in women than men (interaction P < 0.001 for both).

LIMITATIONS:
Power to detect change in body cell mass, potential bias in ascertainment of Subjective Global Assessment.

CONCLUSIONS:

In predialysis patients with CKD, structured nutrition intervention had a greater effect on energy and protein intake in women than men. Additional investigations are warranted to determine the impact on body composition.
Keyword Nutrition intervention
Chronic kidney disease
Predialysis
Randomized controlled trial
Body cell mass
Dietary counseling
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Sat, 28 Mar 2009, 00:43:35 EST by Lisa Hennell on behalf of Faculty Of Health Sciences