Estradiol treatment and its interaction with the cholinergic system: Effects on cognitive function in healthy young women

Bartholomeusz, C., Wesnes, K.A., Kulkarni, J., Vitetta, L., Croft, R. J. and Nathan, P. J. (2008) Estradiol treatment and its interaction with the cholinergic system: Effects on cognitive function in healthy young women. Hormones and Behavior, 54 5: 684-693. doi:10.1016/j.yhbeh.2008.07.007


Author Bartholomeusz, C.
Wesnes, K.A.
Kulkarni, J.
Vitetta, L.
Croft, R. J.
Nathan, P. J.
Title Estradiol treatment and its interaction with the cholinergic system: Effects on cognitive function in healthy young women
Journal name Hormones and Behavior   Check publisher's open access policy
ISSN 0018-506X
Publication date 2008-11-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.yhbeh.2008.07.007
Open Access Status DOI
Volume 54
Issue 5
Start page 684
End page 693
Total pages 10
Editor Etgen, A.M.
Place of publication USA
Publisher Academic Press
Language eng
Subject C1
920507 Women's Health
111502 Clinical Pharmacology and Therapeutics
Abstract The steroid hormone estradiol has been shown to modulate cognitive function in both animals and humans, and although the exact mechanisms associated with these effects are unknown, interactions with the cholinergic system have been proposed. We examined the neurocognitive effects of short-term estradiol treatment and its interaction with the cholinergic system using the muscarinic receptor antagonist scopolamine in healthy young women. Thirty-four participants (Mean age ± SD = 22.4 ± 4.4) completed baseline cognitive assessment and then received either 100 μg/day transdermal estradiol or transdermal placebo for 31 days. On days 28 and 31 of treatment, further cognitive assessment was performed pre- and 90 min post-scopolamine (0.4 mg) or placebo (saline) injection, under a randomized double-blind placebo-controlled design. Short-term estradiol treatment significantly enhanced spatial working memory with a trend for improvement in long-term verbal learning and memory. Overall, estradiol treatment did not protect against or attenuate the scopolamine-induced impairments in the cognitive domains assessed. Findings suggest that estrogen has minimal effects on cholinergic-mediated cognitive processes following short-term treatment. Effects of estradiol treatment may be dependent on age, dose of estradiol, integrity of cholinergic innervation and baseline endogenous estrogen levels, which may in part explain the inconsistent findings in the literature.
Keyword Cholinergic system
Cognition
Estradiol
Healthy young women
Muscarinic receptors
Scopolamine
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 28 Mar 2009, 00:36:50 EST by Denise Wilson on behalf of School of Medicine