Market failure and the poverty of new drugs in maternal health

Fisk, Nicholas M. and Atun, Rifat (2008) Market failure and the poverty of new drugs in maternal health. PloS Med, 5 1: 22-28. doi:10.1371/journal.pmed.0050022

Author Fisk, Nicholas M.
Atun, Rifat
Title Market failure and the poverty of new drugs in maternal health
Journal name PloS Med   Check publisher's open access policy
ISSN 1549-1277
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1371/journal.pmed.0050022
Open Access Status DOI
Volume 5
Issue 1
Start page 22
End page 28
Total pages 7
Editor Virginia Barbour
Place of publication San Francisco, CA, U.S.A.
Publisher Public Library of Science
Language eng
Subject C1
111402 Obstetrics and Gynaecology
920114 Reproductive System and Disorders
1114 Paediatrics and Reproductive Medicine
Formatted abstract
The existing R&D and business model of the pharmaceutical industry has
failed to develop drugs for obstetric conditions, with only one new class of
drug licensed in the past 20 years, and no new class of drug in clinical trials for
primary obstetric applications.  Only 17 drugs are under active development for maternal health indications; less than 3% of the pipeline in cardiovascular health (660 drugs) and fewer than for a single rare disease like amyotrophic lateral sclerosis (34 drugs).  Reasons for the paucity of new drugs for obstetrics include risk aversion, the
cost of reproductive toxicology studies, the small market size, and a weak regulatory system, which encourages endemic off-label use.  Obstetric pathologies have great
impact on maternal and perinatal disease burden in the developing world, yet the paucity of drugs for obstetric disease has attracted little attention from international donor agencies.  We document the global drug drought in maternal health to conclude that the market has failed pregnant women.
Copyright: © 2008 Fisk and Atun.

Keyword Pharmaceutical industry
Maternal health
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Fri, 27 Mar 2009, 20:28:51 EST by Carmen Buttery on behalf of Faculty Of Health Sciences