Major histocompatibility complex class I cytotoxic T lymphocyte immunity to human metapneumovirus (hMPV) in individuals with previous hMPV infection and respiratory disease

Herd, K. A., Nissen, M. D., Hopkins, P. M., Sloots, T. P. and Tindle, R. W. (2008) Major histocompatibility complex class I cytotoxic T lymphocyte immunity to human metapneumovirus (hMPV) in individuals with previous hMPV infection and respiratory disease. The Journal of Infectious Diseases, 197 4: 584-592. doi:10.1086/526536


Author Herd, K. A.
Nissen, M. D.
Hopkins, P. M.
Sloots, T. P.
Tindle, R. W.
Title Major histocompatibility complex class I cytotoxic T lymphocyte immunity to human metapneumovirus (hMPV) in individuals with previous hMPV infection and respiratory disease
Journal name The Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
Publication date 2008-02-15
Year available 2008
Sub-type Article (original research)
DOI 10.1086/526536
Open Access Status
Volume 197
Issue 4
Start page 584
End page 592
Total pages 9
Place of publication Chicago, United States of America
Publisher University of Chicago Press Journals
Language eng
Subject C1
110203 Respiratory Diseases
920109 Infectious Diseases
920108 Immune System and Allergy
110704 Cellular Immunology
11 Medical and Health Sciences
1108 Medical Microbiology
Abstract Recently identified human metapneumovirus (hMPV) is an important respiratory pathogen in children and adults worldwide. Little is known about cytotoxic T lymphocyte (CTL) responses that may control hMPV infection in humans. To address this, we evaluated major histocompatibility complex (MHC) class I T cell immunity in 7 patients with previous hMPV respiratory disease. CTL responses were evident in most patients and to most proteins of hMPV. Individual patients had responses to at least 2 hMPV proteins (particularly the M protein) and had multiallele responses. In addition, we identified 9 CTL epitopes that are presented by human leukocyte antigen alleles of the most common MHC “supertypes.” Many of these CTL epitopes are conserved across hMPV types, and there is epitope similarity between hMPV and human respiratory syncytial virus. This study provides the first report of MHC class I T cell immunity to hMPV in humans. These findings have significance for understanding cellular immunity to hMPV infection and for future vaccine development
Keyword Human metapneumovirus
Cellular immunity
Cytotoxic T-cell
Major histocompatibility antigen
Respiratory Diseases
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
UQ Diamantina Institute Publications
 
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Created: Fri, 27 Mar 2009, 00:46:51 EST by Lesley Arnicar on behalf of UQ Diamantina Institute