Regulation of placental growth hormone secretion in a human trophoblast model-t the effects of hormones and adipokines

Zeck, W, Widberg, Heidi A., Erin Maylin, Desoye, G., Lang, U., McIntyre, Harold D., Prins, Johannes B. and Russell, Anthony W. (2008) Regulation of placental growth hormone secretion in a human trophoblast model-t the effects of hormones and adipokines. Pediatric Research, 63 4: 353-357. doi:10.1203/01.pdr.0000304935.19183.07


Author Zeck, W
Widberg, Heidi A.
Erin Maylin
Desoye, G.
Lang, U.
McIntyre, Harold D.
Prins, Johannes B.
Russell, Anthony W.
Title Regulation of placental growth hormone secretion in a human trophoblast model-t the effects of hormones and adipokines
Journal name Pediatric Research   Check publisher's open access policy
ISSN 0031-3998
Publication date 2008-04-01
Year available 2008
Sub-type Article (original research)
DOI 10.1203/01.pdr.0000304935.19183.07
Open Access Status
Volume 63
Issue 4
Start page 353
End page 357
Total pages 5
Place of publication The United States of America
Publisher Int Pediatric Research Foundation
Language eng
Subject C1
110306 Endocrinology
920106 Endocrine Organs and Diseases (excl. Diabetes)
Abstract Placental growth hormone (PGH) is secreted from the human placental syncytiotrophoblast into the maternal circulation. PGH levels in pregnant women correlate with the birth weight of their offspring. We hypothesized. that metabolic regulators may alter PGH secretion. BeWo cells as human trophoblast models were treated for 24, 48, and 72 It with insulin, insulin-like growth factor (IGF)-1, cortisol, ghrelin, leptin and visfatin. Cyclic-adenosinmonophosphate treatment served as positive control. PGH concentrations in culture media were measured. Insulin reduced (p < 0.008; analysis of variance) PGH secretion from BeWo cells after 72 h. No effect was found when treating cells with IGF-1. Cortisol reduced PGH secretion after 48 h (p < 0.00118; analysis of variance) and 72 h (p < 0.015). Leptin and ghrelin both suppressed (p < 0.027 and p < 0.017, paired t test) whereas visfatin increased.(p < 0.014, paired t test) PGH secretion at 72 h. Cyclic adenosinmonophosphate increased (p < 0.003) PGH secretion at 72 h. Our results indicate that in vitro PGH secretion by BeWo cells is regulated by hormonal factors and adipokines. We speculate on the existence of a maternal-placental regulatory loop, in which elevated insulin and leptin levels might down-regulate PGH secretion.
Keyword Pediatrics
Pediatrics
PEDIATRICS
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
UQ Diamantina Institute Publications
 
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Created: Thu, 26 Mar 2009, 23:56:20 EST by Kylie Hengst on behalf of UQ Diamantina Institute