Genetically modified hepatitis B surface antigen: A Powerful vaccine technology for the delivery of disease-associated foreign antigens.

Thomson, S., Haigh, O., Gould, A. R. and Tindle, R. W. (2008) Genetically modified hepatitis B surface antigen: A Powerful vaccine technology for the delivery of disease-associated foreign antigens.. Current Drug Therapy, 3 3: 226-234. doi:10.2174/157488508785747844


Author Thomson, S.
Haigh, O.
Gould, A. R.
Tindle, R. W.
Title Genetically modified hepatitis B surface antigen: A Powerful vaccine technology for the delivery of disease-associated foreign antigens.
Journal name Current Drug Therapy   Check publisher's open access policy
ISSN 1574-8855
Publication date 2008-09-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/157488508785747844
Volume 3
Issue 3
Start page 226
End page 234
Total pages 9
Editor Wernicke, J. F.
Place of publication Netherlands
Publisher Bentham Science Publishers Ltd.
Language eng
Subject C1
060506 Virology
111505 Pharmacogenomics
920109 Infectious Diseases
920108 Immune System and Allergy
Abstract The surface antigen of hepatitis B virus (HBsAg) spontaneously aggregates into ‘empty’ virus-like particles (VLPs) in the absence of other viral components. The powerful immunogenicity of HBsAg when administered either as VLPs or as naked DNA invites it’s exploitation as a vector for the delivery of antigenic determinants from other organisms. Here we discuss ways in which HBsAg may be modified to derive vaccines against disease-related pathogens. We review studies demonstrating the induction of disease-protective antibody and T-cell responses induced by immunization with recombinant HBsAg vaccines, and consider how these vaccines might best be delivered. Unmodified HBsAg VLPs are licensed for use in humans as the pan-global vaccine to prevent hepatitis B virus infection, suggesting that route-to-market for recombinant HBsAg vaccines might be simplified.
Keyword Hepatitis B Surface Antigen
Vaccine Design
DNA
virus-like particle
cytotoxic T-cell
antibody
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes No DOI could be located.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: 2009 Higher Education Research Data Collection
 
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Created: Thu, 26 Mar 2009, 23:42:23 EST by Lesley Arnicar on behalf of Clinical Medical Virology Centre