Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: Evidence of a weak association in Finns

Pointon, J. J., Chapman, K., Harvey, D., Sims, Anne-Marie, Linda Bradbury, Laiho, K., Kauppi, M., Kaarela, K., Tuomilehto, J., Brown, Matthew A. and Wordsworth, B. P. (2008) Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: Evidence of a weak association in Finns. Journal of Rheumatology, 35 8: 1609-1612. doi:10.3899/jrheum.080085C1


Author Pointon, J. J.
Chapman, K.
Harvey, D.
Sims, Anne-Marie
Linda Bradbury
Laiho, K.
Kauppi, M.
Kaarela, K.
Tuomilehto, J.
Brown, Matthew A.
Wordsworth, B. P.
Title Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: Evidence of a weak association in Finns
Journal name Journal of Rheumatology   Check publisher's open access policy
ISSN 0315-162X
Publication date 2008-08-01
Year available 2008
Sub-type Article (original research)
DOI 10.3899/jrheum.080085C1
Open Access Status Not yet assessed
Volume 35
Issue 8
Start page 1609
End page 1612
Total pages 4
Place of publication Toronto, Ont., Canada
Publisher Journal of Rheumatology Publishing Co.
Language eng
Subject C1
920116 Skeletal System and Disorders (incl. Arthritis)
110322 Rheumatology and Arthritis
Abstract Objective. To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS). Methods. A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed. Results. In the Finnish study the CD74-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses. Conclusion. CD14 and TLR4 showed an association with AS in the Finns only.
Formatted abstract
Objective.
To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS).

Methods.
A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed.

Results.
In the Finnish study the CD74-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses.

Conclusion.

CD14 and TLR4 showed an association with AS in the Finns only.


Keyword Ankylosing spondylitis
Genetic studies
Immune system
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Erratum: Pointon JJ, Chapman K, Harvey D, SimsA-M, Bradbury L, Laiho K, Kauppi M, Kaarela K, Tuomilehto J, Brown MA, Wordsworth BP. Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: Evidence of a weak association in Finns. J Rheumatol 2008-35:1609-12.Acknowledgment of funding sources should have included the Oxford Radcliffe Hospital Biomedical Research Centre ankylosing spondylitis chronic disease cohort (Theme Code: A91202).We regret the error.

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
UQ Diamantina Institute Publications
 
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Created: Thu, 26 Mar 2009, 21:51:18 EST by Kylie Hengst on behalf of UQ Diamantina Institute