Short-term outcomes of five heroin detoxification methods in the Australian NEPOD Project

The NEPOD Research Group, Digiusto, Erol, Lintzeris, Nicholas, Breen, Courtney, Kimber, Jo, Mattick, Richard P., Bell, James, Ali, Robert, Saunders, John B. and Doran, Chris (2005) Short-term outcomes of five heroin detoxification methods in the Australian NEPOD Project. Addictive Behaviors, 30 3: 443-456. doi:10.1016/j.addbeh.2004.06.002

Author The NEPOD Research Group
Digiusto, Erol
Lintzeris, Nicholas
Breen, Courtney
Kimber, Jo
Mattick, Richard P.
Bell, James
Ali, Robert
Saunders, John B.
Doran, Chris
Title Short-term outcomes of five heroin detoxification methods in the Australian NEPOD Project
Journal name Addictive Behaviors   Check publisher's open access policy
ISSN 0306-4603
Publication date 2005-03-01
Sub-type Article (original research)
DOI 10.1016/j.addbeh.2004.06.002
Open Access Status DOI
Volume 30
Issue 3
Start page 443
End page 456
Total pages 14
Place of publication Oxford, United Kingdom
Publisher Pergamon
Language eng
Subject 1117 Public Health and Health Services
110319 Psychiatry (incl. Psychotherapy)
Abstract This study included 380 participants in five heroin detoxification trials whose data were pooled to enable direct comparison of five detoxification methods in the Australian National Evaluation of Pharmacotherapies for Opioid Dependence (NEPOD). Rapid detoxification achieved similar initial abstinence rates with either anaesthesia or sedation (average 59%), which were higher than was achieved by inpatient detoxification using clonidine plus other symptomatic medications (24%), which in turn was higher than outpatient detoxification using either buprenorphine (12%) or clonidine plus other symptomatic medications (4%). Older participants and those using more illicit drugs were more likely to achieve abstinence. Entry rates into ongoing postdetoxification treatment were as follows: buprenorphine outpatient (65%), sedation (63%), anaesthesia (42%), symptomatic outpatient (27%), and symptomatic inpatient (12%). Postdetoxification treatment with buprenorphine or methadone was preferred over naltrexone. Participants with more previous detoxification attempts were more likely to enter postdetoxification treatment. Given that outpatient detoxification was more effective with buprenorphine than with symptomatic medications and that rapid detoxification was more effective than the symptomatic inpatient method, the roles of the symptomatic methods should be reconsidered.
Keyword Heroin
Drug rehabilitation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Created: Wed, 25 Mar 2009, 20:56:49 EST by Sophie Jordan on behalf of Speech Pathology and Audiology