Molecular Study of Echinococcus in West-Central China

Yang, Y. R., Rosenzvit, M. C., Zhang, L. H., Zhang, J. Z. and McManus, D. P. (2005) Molecular Study of Echinococcus in West-Central China. Parasitology, 131 4: 547-555. doi:10.1017/S0031182005007973


Author Yang, Y. R.
Rosenzvit, M. C.
Zhang, L. H.
Zhang, J. Z.
McManus, D. P.
Title Molecular Study of Echinococcus in West-Central China
Journal name Parasitology   Check publisher's open access policy
ISSN 1469-8161
0031-1820
Publication date 2005-10-01
Year available 2005
Sub-type Article (original research)
DOI 10.1017/S0031182005007973
Open Access Status
Volume 131
Issue 4
Start page 547
End page 555
Total pages 9
Editor Robin B. Gasser
Place of publication London
Publisher Cambridge University Press
Language eng
Subject 1117 Public Health and Health Services
Abstract West-central China is an important endemic focus of both alveolar and cystic echinococcosis where several species of intermediate host are commonly infected with Echinococcus granulosus and E. multilocularis. Isolates of E. granulosus were collected from humans and other animals from different geographical areas of Qinghai, Ningxia, Gansu and Sichuan, and genotyped using the mitochondrial DNA marker ATP synthase subunit 6 gene (atp6). The sheep strain (G1 genotype) of E. granulosus was shown to be the only genotype present in sheep, cattle, goats, yaks and humans in the study areas. However, some heterogeneity in the atp6 sequence was evident in a number of the isolates with the most frequent change being a silent substitution (G/A) at position 360 compared with the G1 reference sequence representing isolates collected from the majority of hosts except humans. Two E. multilocularis isolates examined also had sequences that varied from each other and from the reference E. multilocularis atp6 sequence. The genotypic variation we report may reflect phenotypic differences with important consequences in terms of increased host infectivity for hosts by local Echinococcus strains, possibly impacting on the epidemiology and control of echinococcosis. Such adaptations may also result in different sensitivity to drugs or increased virulence for hosts that will impede control efforts and even affect vaccination strategies against Echinococcus.
Keyword Echinococcus granulosus
Echinococcus multilocularis
echinococcosis
mitochondrial atp6 sequence
west-central China
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Published online by Cambridge University Press 10 June 2005

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Created: Wed, 25 Mar 2009, 20:10:56 EST by Maryanne Watson on behalf of School of Public Health