Endometrioid and clear cell ovarian cancers - A comparative analysis of risk factors

Nagle, C, Olsen, Catherine, Webb, P, Susan Jordan, Whiteman, D and Green, A (2008) Endometrioid and clear cell ovarian cancers - A comparative analysis of risk factors. European Journal of Cancer, 44 16: 2477-2484. doi:10.1016/j.ejca.2008.07.009


Author Nagle, C
Olsen, Catherine
Webb, P
Susan Jordan
Whiteman, D
Green, A
Title Endometrioid and clear cell ovarian cancers - A comparative analysis of risk factors
Journal name European Journal of Cancer   Check publisher's open access policy
ISSN 0959-8049
1359-6349
Publication date 2008-08-15
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.ejca.2008.07.009
Open Access Status DOI
Volume 44
Issue 16
Start page 2477
End page 2484
Total pages 8
Editor John Smyth
Place of publication The United Kingdom
Publisher Pergamon
Language eng
Subject C1
920102 Cancer and Related Disorders
111299 Oncology and Carcinogenesis not elsewhere classified
Abstract Endometrioid and clear cell subtypes of ovarian cancer are both known to be closely associated with endometriosis and endometrial pathology, and so have often been combined in studies of causation. We have examined these ovarian cancers separately for potentially distinct risk factors in our population-based, Australia-wide case control study of 142 women with incident invasive endometrioid, 90 with clear cell ovarian cancers and 1508 population controls. Multivariate logistic regression was used to calculated odds ratios (ORs) and 95% confidence intervals (CIs). Increasing parity, and hormonal contraceptive use for >= 5 years, strongly decreased the risks of both subtypes. Breast feeding and tubal ligation were also inversely associated, but significantly so only for the endometrioid subtype. As expected endometriosis increased the risk of both subtypes (OR 2.2, 95%CI 1.2-3.9 for endometrioid and OR 3.0, 95%CI 1.5-5.9 for clear cell). Obesity was associated only with clear cell cancers, where we observed a two-fold increased risk (OR 2.2, 95%CI 1.2-4.1). Also a significant trend of decreasing risk with increasing intensity of smoking (p trend 0.02) and education beyond high school was associated with decreased development of clear cell cancers only. Endometrioid and clear cell ovarian cancers have some shared as well as some distinct risk factors, and therefore should be considered separately in studies of ovarian cancer. (C) 2008 Elsevier Ltd. All rights reserved.
Keyword Oncology
Oncology
ONCOLOGY
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
2009 Higher Education Research Data Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 45 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 25 Mar 2009, 20:08:04 EST by Geraldine Fitzgerald on behalf of School of Public Health