Properties of a formulated paediatric phenobarbitone oral liquid

Garg, S., Svirskis, D., Myftiu, J., Behayaa, M., Shahin, D., Thrimawithana, T., Vidicki, A. and Kairuz, T. (2008) Properties of a formulated paediatric phenobarbitone oral liquid. Journal of Pharmacy Practice and Research, 38 1: 28-31.

Author Garg, S.
Svirskis, D.
Myftiu, J.
Behayaa, M.
Shahin, D.
Thrimawithana, T.
Vidicki, A.
Kairuz, T.
Title Properties of a formulated paediatric phenobarbitone oral liquid
Journal name Journal of Pharmacy Practice and Research   Check publisher's open access policy
ISSN 1145-937X
Publication date 2008-01-01
Sub-type Article (original research)
Volume 38
Issue 1
Start page 28
End page 31
Total pages 4
Editor Brien, J. E.
Place of publication Victoria
Publisher SHPA
Language eng
Subject 111503 Clinical Pharmacy and Pharmacy Practice
730399 Health and support services not elsewhere classified
C1
Abstract Aim: To formulate a stable and palatable paediatric phenobarbitone 10 mg/mL oral liquid and compare its physicochemical stability to the existing formulation compounded in some New Zealand hospitals. Method: Formulations were compounded from pharmaceutical standard ingredients according to good manufacturing practices and stored in glass bottles at different storage conditions. The physical stability of the formulations was determined by pH, appearance, viscosity and microbial studies; chemical stability was assessed using high performance liquid chromatography. Results: The new formulation and the existing hospital formulation remained physically stable for 28 days in terms of pH, appearance, viscosity and microbial stability. The phenobarbitone sodium concentration remained within an acceptable range (above 95% of the original concentration) after 28 days of storage at different conditions. The viscosity of the new formulation facilitated in masking phenobarbitone sodium's bitter taste, thus improving palatability. The palatability of the new formulation was superior to the hospital formulation. Conclusion: A palatable paediatric phenobarbitone oral liquid formulation with improved theological properties was developed. (author abstract)
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Pharmacy Publications
 
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Created: Wed, 25 Mar 2009, 18:53:30 EST by Elizabeth Pyke on behalf of School of Pharmacy