Pre-mRNA splicing aberrations and cancer

Pettigrew, C.A. and Brown, M.A. (2008) Pre-mRNA splicing aberrations and cancer. Frontiers In Bioscience, 13 13: 1090-1105. doi:10.2741/2747

Author Pettigrew, C.A.
Brown, M.A.
Title Pre-mRNA splicing aberrations and cancer
Journal name Frontiers In Bioscience   Check publisher's open access policy
ISSN 1093-9946
Publication date 2008-01-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2741/2747
Open Access Status
Volume 13
Issue 13
Start page 1090
End page 1105
Total pages 16
Place of publication United States
Publisher Frontiers in Bioscience
Language eng
Subject C1
060407 Genome Structure and Regulation
110203 Respiratory Diseases
920102 Cancer and Related Disorders
920507 Women's Health
Abstract Splicing requires the accurate recognition of exonic sequences from the surrounding thousands of nucleotides of intronic sequence and is achieved by the coordinate interplay of splicing regulatory elements in genes and the trans-acting RNA and protein molecules to which they bind. Infidelity in this process can have dramatic consequences for protein production, with an errors resulting in mRNA instability or the production of aberrant protein products. It is therefore not surprising that disruptions of splicing processes have been associated with a wide range of diseases, including cancer. This review looks at some of the mechanisms that regulate splicing and how disruption of such mechanisms can contribute to cancer susceptibility and progression.
Keyword Biochemistry & Molecular Biology
Cell Biology
Biochemistry & Molecular Biology
Cell Biology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 29 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 31 times in Scopus Article | Citations
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Created: Wed, 25 Mar 2009, 01:39:30 EST by Jennifer Falknau on behalf of School of Chemistry & Molecular Biosciences