Genetic susceptibility to the respiratory effects of air pollution

Yang, I. A., Fong, K. M., Zimmerman, P. V., Holgate, S. T. and Holloway, J. W. (2008) Genetic susceptibility to the respiratory effects of air pollution. Thorax, 63 6: 555-563. doi:10.1136/thx.2007.079426


Author Yang, I. A.
Fong, K. M.
Zimmerman, P. V.
Holgate, S. T.
Holloway, J. W.
Title Genetic susceptibility to the respiratory effects of air pollution
Journal name Thorax   Check publisher's open access policy
ISSN 0040-6376
Publication date 2008-06-01
Year available 2008
Sub-type Article (original research)
DOI 10.1136/thx.2007.079426
Open Access Status Not yet assessed
Volume 63
Issue 6
Start page 555
End page 563
Total pages 9
Editor S. Johnston
J.A. Wedzicha
Place of publication London. U.K.
Publisher BMJ Group
Language eng
Subject C1
920115 Respiratory System and Diseases (incl. Asthma)
110203 Respiratory Diseases
1103 Clinical Sciences
Abstract There is large variation between individuals in their response to air pollutants. This review summarises the existing evidence that genetic factors influence the mechanisms of lung injury caused by air pollutants. Genetic association studies have compared the adverse effects of air pollutants between subjects with specific genotypes in biologically relevant genes. In human studies of ozone exposure, polymorphisms in oxidative stress genes (NQO1, GSTM1, GSTP1) modify respiratory symptoms, lung function, biomarkers and risk of asthma. Inflammatory gene polymorphisms (TNF) influence the lung function response to ozone, and the effect of different levels of ozone on the development of asthma. Polymorphisms in oxidative stress genes (GSTM1, GSTP1) alter the response to combined exposure to ragweed pollen and diesel exhaust particles. Importantly, polymorphisms in an oxidative stress gene (GSTM1) have predicted patients with asthma who benefit from antioxidant supplementation in Mexico City, which has chronically high ozone exposure. Genetic linkage studies of families have not been feasible for studying the effects of air pollution in humans, but some progress has been made with pedigrees of specially bred mice, in identifying chromosomal regions linked to effects of ozone or particles. A high priority now, in addition to avoiding exposure in the most susceptible people, is to clearly identify the most effective and safe chemopreventive agents for individuals who are genetically susceptible to the adverse effects of air pollution (eg, antioxidants to be taken during high ozone levels).
Keyword Air pollution
Pollutants
Asthma
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID G0800766
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 25 Mar 2009, 00:53:35 EST by Diana Steenberg on behalf of Medicine - Royal Brisbane and Women's Hospital