Human papillomavirus type spectrum in normal skin of individuals with or without a history of frequent sun exposure

Chen, Alice Che-Ha, McMillan, Nigel A.J. and Antonsson, Annika (2008) Human papillomavirus type spectrum in normal skin of individuals with or without a history of frequent sun exposure. Journal of General Virology, 89 11: 2891-2897. doi:10.1099/vir.0.2008/003665-0


Author Chen, Alice Che-Ha
McMillan, Nigel A.J.
Antonsson, Annika
Title Human papillomavirus type spectrum in normal skin of individuals with or without a history of frequent sun exposure
Journal name Journal of General Virology   Check publisher's open access policy
ISSN 0022-1317
1465-2099
Publication date 2008-11-01
Year available 2008
Sub-type Article (original research)
DOI 10.1099/vir.0.2008/003665-0
Open Access Status
Volume 89
Issue 11
Start page 2891
End page 2897
Total pages 7
Place of publication Reading, Berks, United Kingdom
Publisher Society for General Microbiology
Language eng
Abstract Cutaneous human papillomavirus (HPV) has been widely detected in healthy skin. Previous studies have found that UV radiation can activate several HPV types, and a possible role for cutaneous HPV in the development of non-melanoma skin cancer has been suggested. This study investigated the prevalence and type-spectrum of cutaneous HPV in relation to UV radiation by studying forehead skin swab samples from 50 healthy males frequently exposed to the sun and 50 healthy males who were not frequently exposed to the sun. A questionnaire including ethnic background of the participants, history of cancers and a self-assessment of sun-exposure was also conducted and analysed. PCR with the FAP primer pair was carried out to detect HPV DNA in samples. HPV prevalence was higher in individuals who spent more time outdoors and in individuals with a history of skin cancers (P=0.044 and P=0.04, respectively). Furthermore, individuals wearing sunglasses as a means of sun protection had a lower prevalence of HPV (P=0.018). Interestingly, HPV-76 was only detected in the group without frequent sun-exposure (P=0.001). These results suggest that increased UV radiation exposure may be a factor leading to a difference in prevalence of cutaneous HPV types. The GenBank/EMBL/DDBJ accession number for the partial L1 sequence of the putative new HPV type FADI1 is EU340869.
Keyword Cutaneous human papillomavirus
Papillomavirus
Skin cancers
Sun protection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 29 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 29 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 25 Mar 2009, 00:35:20 EST by Kylie Hengst on behalf of UQ Diamantina Institute