Molecular basis of pathogenesis, prognosis and therapy in chronic lymphocytic leukaemia

Chen, Jiezhong and McMillan, Nigel A. J. (2008) Molecular basis of pathogenesis, prognosis and therapy in chronic lymphocytic leukaemia. Cancer biology & therapy, 7 2: 174-179. doi:10.4161/cbt.7.2.5262


Author Chen, Jiezhong
McMillan, Nigel A. J.
Title Molecular basis of pathogenesis, prognosis and therapy in chronic lymphocytic leukaemia
Journal name Cancer biology & therapy   Check publisher's open access policy
ISSN 1538-4047
Publication date 2008-02-01
Year available 2008
Sub-type Article (original research)
DOI 10.4161/cbt.7.2.5262
Open Access Status
Volume 7
Issue 2
Start page 174
End page 179
Total pages 6
Place of publication Georgetown, TX, USA
Publisher Landes Bioscience
Language eng
Subject C1
111201 Cancer Cell Biology
920102 Cancer and Related Disorders
Abstract B-cell chronic lymphocytic leukemia (CLL) is caused by the abnormal accumulation of non-functional B-cells in peripheral blood and bone marrow. However, the precise aetiology and mechanism of the disease are unclear. Recently, progress has been made in the identification of both the genetic deficiencies and environmental factors that may underlie CLL. This has provided some clues to the nature of the disease, but no definitive cures. Although treatment has increased remission time, at present the disease is not curable by conventional therapy. Further studies of the pathogenesis of CLL are needed, as are the development of suitable cell lines and animal models in which to study it. This review summarises the most recent progress in CLL with emphasis on molecular events and possible implications in therapy.
Keyword CLL
signal transduction
BCR
PI3K
Akt
p53
MiRNA
PKR
Bcl2
Src
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
UQ Diamantina Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 29 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 24 Mar 2009, 23:17:07 EST by Kylie Hengst on behalf of UQ Diamantina Institute