Mixed system of Eudragit S-100 with a designed amphipathic peptide: Control of interfacial elasticity by solution composition

Dexter, Annette F., Malcolm, Andrew S., Zeng, Biyun, Kennedy, Debora and Middelberg, Anton P. J. (2008) Mixed system of Eudragit S-100 with a designed amphipathic peptide: Control of interfacial elasticity by solution composition. Langmuir, 24 7: 3045-3052. doi:10.1021/la703252r


Author Dexter, Annette F.
Malcolm, Andrew S.
Zeng, Biyun
Kennedy, Debora
Middelberg, Anton P. J.
Title Mixed system of Eudragit S-100 with a designed amphipathic peptide: Control of interfacial elasticity by solution composition
Journal name Langmuir   Check publisher's open access policy
ISSN 1520-5827
Publication date 2008-04-01
Year available 2008
Sub-type Article (original research)
DOI 10.1021/la703252r
Open Access Status
Volume 24
Issue 7
Start page 3045
End page 3052
Total pages 8
Place of publication Washington, DC
Publisher American Chemical Society
Language eng
Subject C1
030603 Colloid and Surface Chemistry
860699 Industrial Chemicals and Related Products not elsewhere classified
Abstract We report an interfacially active system based on an informational peptide surfactant mixed with an oppositely charged polyelectrolyte. The 21-residue cationic peptide, AM1, has previously been shown to respond reversibly to pH and metal ions at fluid interfaces, forming elastic films that can be rapidly switched to collapse foams or emulsions on demand. Here we report the reversible association of AM1 with the methacrylate-based anionic polymer Eudragit S-100. The strength of the association, in bulk aqueous solution, is modulated by added metal ions and by ionic strength. Addition of zinc ions to the peptide−polymer system promotes complex formation and phase separation, while addition of a chelating agent reverses the association. The addition of salt weakens peptide−polymer interactions in the presence or absence of zinc. At the air−water interface, Eudragit S-100 forms an elastic mixed film with AM1 in the absence of metal, under conditions where the peptide alone does not show interfacial elasticity. When zinc is present, the elasticity of the mixed film is increased, but the rate of interfacial adsorption slows due to formation of peptide−polymer complexes in bulk solution. An understanding of these interactions can be used to identify favorable foam-forming conditions in the mixed system.
Keyword Sodium Dodecyl-sulfate
Polyelectrolyte-Surfactant Complexes
Oppositely Charged Surfactants
Air-Solution Interface
Colonic Drug-Delivery
Helical Coiled Coils
Mechanical-properties
Aqueous-solution
protein networks
Water-interface
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Publication Date (Web): February 15, 2008

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Tue, 24 Mar 2009, 23:08:29 EST by Mrs Jennifer Brown on behalf of Aust Institute for Bioengineering & Nanotechnology