Subcellular localization of the Schlafen protein family

Neumann, Brent, Zhao, Liang, Murphy, Kathleen and Gonda, Thomas J. (2008) Subcellular localization of the Schlafen protein family. Biochemical and Biophysical Research Communications, 370 1: 62-66. doi:10.1016/j.bbrc.2008.03.032


Author Neumann, Brent
Zhao, Liang
Murphy, Kathleen
Gonda, Thomas J.
Title Subcellular localization of the Schlafen protein family
Journal name Biochemical and Biophysical Research Communications   Check publisher's open access policy
ISSN 0006-291X
Publication date 2008-05-23
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.bbrc.2008.03.032
Open Access Status
Volume 370
Issue 1
Start page 62
End page 66
Total pages 5
Place of publication San Diego CA, USA
Publisher Academic Press
Language eng
Subject C1
060103 Cell Development, Proliferation and Death
920102 Cancer and Related Disorders
970106 Expanding Knowledge in the Biological Sciences
Abstract Although the first members of the Schlafen gene family were first described almost 10 years ago, the precise molecular/biochemical functions of the proteins they encode still remain largely unknown. Roles in cell growth, haematopoietic cell differentiation, and T cell development/maturation have, with some experimental support, been postulated, but none have been conclusively verified. Here, we have determined the subcellular localization of Schlafens 1, 2, 4, 5, 8, and 9, representing all three of the murine subgroups. We show that the proteins from subgroups I and II localize to the cytoplasm, while the longer forms in subgroup III localize exclusively to the nuclear compartment. We also demonstrate upregulation of Schlafen2 upon differentiation of haematopoietic cells and show this endogenous protein localizes to the cytoplasm. Thus, we propose the different subgroups of Schlafen proteins are likely to have functionally distinct roles, reflecting their differing localizations within the cell.
Keyword Murine
Schlafen
Subcellular localization
Cytoplasm
Nucleus
Differentiation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 18 March 2008.

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
UQ Diamantina Institute Publications
 
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Created: Tue, 24 Mar 2009, 22:29:45 EST by Kylie Hengst on behalf of UQ Diamantina Institute