Anthropometric Factors and Risk of Endometrial Cancer: the European Prospective Investigation into Cancer and Nutrition

Friedenreich, Christine, Cust, Anne, Lahmann, Petra H., Steindorf, Karen, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Francoise, Mesrine, Sylvie, Linseisen, Jakob, Rohrmann, Sabine, Boeing, Heiner, Pischon, Tobias, Tjønneland, Anne, Halkjær, Jytte, Overvad, Kim, Mendez, Michelle, Redondo, M. L., Garcia, Carmen Martinez, Larranaga,, Nerea, Tormo, Marıa-Jose´, Gurrea, Aurelio Barricarte, Bingham, Sheila, Khaw, Kay-Tee, Allen, Naomi, Key, Tim, Trichopoulou, Antonia, Vasilopoulou, Effie, Trichopoulos, Dimitrios, Pala, Valeria, Palli, Domenico, Tumino, Rosario, Mattiello, Amalia, Vineis, Paolo, Bueno-de-Mesquita, H. Bas, Peeters, Petra H. M., Berglund, Goran, Manjer, Jonas, Lundin, Eva, Lukanova, Annekatrin, Slimani, Nadia, Jenab, Mazda, Kaaks, Rudolf and Riboli, Elio (2007) Anthropometric Factors and Risk of Endometrial Cancer: the European Prospective Investigation into Cancer and Nutrition. Cancer Causes and Control, 18 4: 399-413. doi:10.1007/s10552-006-0113-8

Author Friedenreich, Christine
Cust, Anne
Lahmann, Petra H.
Steindorf, Karen
Boutron-Ruault, Marie-Christine
Clavel-Chapelon, Francoise
Mesrine, Sylvie
Linseisen, Jakob
Rohrmann, Sabine
Boeing, Heiner
Pischon, Tobias
Tjønneland, Anne
Halkjær, Jytte
Overvad, Kim
Mendez, Michelle
Redondo, M. L.
Garcia, Carmen Martinez
Larranaga,, Nerea
Tormo, Marıa-Jose´
Gurrea, Aurelio Barricarte
Bingham, Sheila
Khaw, Kay-Tee
Allen, Naomi
Key, Tim
Trichopoulou, Antonia
Vasilopoulou, Effie
Trichopoulos, Dimitrios
Pala, Valeria
Palli, Domenico
Tumino, Rosario
Mattiello, Amalia
Vineis, Paolo
Bueno-de-Mesquita, H. Bas
Peeters, Petra H. M.
Berglund, Goran
Manjer, Jonas
Lundin, Eva
Lukanova, Annekatrin
Slimani, Nadia
Jenab, Mazda
Kaaks, Rudolf
Riboli, Elio
Title Anthropometric Factors and Risk of Endometrial Cancer: the European Prospective Investigation into Cancer and Nutrition
Journal name Cancer Causes and Control   Check publisher's open access policy
ISSN 0957-5243
Publication date 2007-05-01
Sub-type Article (original research)
DOI 10.1007/s10552-006-0113-8
Open Access Status DOI
Volume 18
Issue 4
Start page 399
End page 413
Total pages 15
Editor E. Giovannucci
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Language eng
Subject 1117 Public Health and Health Services
Formatted abstract
Objective To examine the association between anthropometry and endometrial cancer, particularly by menopausal status and exogenous hormone use subgroups. Methods Among 223,008 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, there were 567 incident endometrial cancer cases during 6.4 years of follow-up. The analysis was performed with Cox proportional hazards modeling. Results Weight, body mass index (BMI), waist and hip circumferences and waist–hip ratio (WHR) were strongly associated with increased risk of endometrial cancer. The relative risk (RR) for obese (BMI 30– < 40 kg/m2) compared to normal weight (BMI < 25) women was 1.78, 95% CI = 1.41–2.26, and for morbidly obese women (BMI ≥ 40) was 3.02, 95% CI = 1.66–5.52. The RR for women with a waist circumference of ≥88 cm vs. <80 cm was 1.76, 95% CI = 1.42–2.19. Adult weight gain of ≥20 kg compared with stable weight (±3 kg) increased risk independent of body weight at age 20 (RR = 1.75, 95% CI = 1.11–2.77). These associations were generally stronger for postmenopausal than premenopausal women, and oral contraceptives never-users than ever-users, and much stronger among never-users of hormone replacement therapy compared to ever-users. Conclusion Obesity, abdominal adiposity, and adult weight gain were strongly associated with endometrial cancer risk. These associations were particularly evident among never-users of hormone replacement therapy.

Keyword Anthropometry
Endometrial cancer
Risk factors
Hormone replacement therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 110 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 24 Mar 2009, 22:24:24 EST by Juliette Grosvenor on behalf of School of Public Health