Renal ageing: Changes in the cellular mechanism of energy metabolism and oxidant handling

Percy, C.J., Power, D. and Gobe, G.C. (2008) Renal ageing: Changes in the cellular mechanism of energy metabolism and oxidant handling. Nephrology, 13 2: 147-152. doi:10.1111/j.1440-1797.2008.00924.x


Author Percy, C.J.
Power, D.
Gobe, G.C.
Title Renal ageing: Changes in the cellular mechanism of energy metabolism and oxidant handling
Journal name Nephrology   Check publisher's open access policy
ISSN 1320-5358
Publication date 2008-01-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1440-1797.2008.00924.x
Open Access Status
Volume 13
Issue 2
Start page 147
End page 152
Total pages 6
Editor Harris, D.
Place of publication Richmond, Victoria
Publisher Wiley-Blackwell Publishing Asia
Language eng
Subject C1
110312 Nephrology and Urology
920119 Urogenital System and Disorders
Abstract The age-dependent changes in the kidney are often debilitating, can be life-threatening and are a significant cause of increasing health costs worldwide. Excessive fibrosis, a general lack of regenerative ability and an increase in apoptosis in cells that determine healthy renal function work together to cause chronic kidney disease. This review provides information on the molecules and mechanisms that determine the age-dependent effects in the kidney, and in particular, the effects of cellular metabolism and oxidant handling on the ageing kidney. With a better understanding of the influence of ageing on the structural and functional alterations that occur, new targeted therapies may be developed to minimize renal damage and promote health in the elderly.
Keyword Urology & Nephrology
Urology & Nephrology
UROLOGY & NEPHROLOGY
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2009 Higher Education Research Data Collection
UQ Centre for Clinical Research Publications
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 25 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 30 times in Scopus Article | Citations
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Created: Tue, 24 Mar 2009, 21:52:59 EST by Brenda Mason on behalf of Molecular and Cellular Pathology - Sch of Med Cent