The "Fas counterattack" is not an active mode of tumor immune evasion in colorectal cancer with high-level microsatellite instability

Houston, AM, Michael-Robinson, JM, Walsh, MD, Cummings, MC, Ryan, AE, Lincoln, D, Pandeya, N, Jass, JR, Radford-Smith, GL and O'Connell, J (2008) The "Fas counterattack" is not an active mode of tumor immune evasion in colorectal cancer with high-level microsatellite instability. Human Pathology, 39 2: 243-250. doi:10.1016/j.humpath.2007.06.010


Author Houston, AM
Michael-Robinson, JM
Walsh, MD
Cummings, MC
Ryan, AE
Lincoln, D
Pandeya, N
Jass, JR
Radford-Smith, GL
O'Connell, J
Title The "Fas counterattack" is not an active mode of tumor immune evasion in colorectal cancer with high-level microsatellite instability
Journal name Human Pathology   Check publisher's open access policy
ISSN 0046-8177
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.humpath.2007.06.010
Open Access Status
Volume 39
Issue 2
Start page 243
End page 250
Total pages 8
Place of publication Philadelphia, U.S.A.
Publisher W B Saunders
Language eng
Subject C1
110316 Pathology (excl. Oral Pathology)
920102 Cancer and Related Disorders
Abstract Microsatellite instability (MSI) is an alternative pathway of colorectal carcinogenesis. It is found in 10% to 15% of sporadic colorectal neoplasms and is characterized by failure of the DNA mismatch-repair system. High-level MSI (MSI-H) is associated with tumor-infiltrating lymphocytes (TILs) and a favorable prognosis. Expression of Fas ligand (FasL/CD95L) by cancer cells may mediate tumor immune privilege by inducing apoptosis of antitumor immune cells. The aim of this study was to investigate the relationship between FasL expression and MSI status in primary colon tumors. Using immunohistochemistry, we detected FasL expression in 91 colorectal carcinoma specimens, previously classified according to the level of MSI as MSI-H (n = 26), MSI-low (MSI-L) (n = 29), and microsatellite stable (n = 36). Tumor-infiltrating lymphocyte density was quantified by immunohistochemical staining for CD3. MSI-H tumors were significantly associated with reduced frequency (P = .04) and intensity (P = .066) of FasL expression relative to non-MSI-H (ie, microsatellite stable and MSI-L) tumors. Higher FasL staining intensity correlated with reduced TIL density (P = .059). Together, these findings suggest that the abundance of TILs found in MSI-H tumors may be due to the failure of these tumor cells to up-regulate FasL and may explain, in part, the improved prognosis associated with these tumors.
Keyword Pathology
Pathology
PATHOLOGY
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Tue, 24 Mar 2009, 21:40:10 EST by Brenda Mason on behalf of Molecular and Cellular Pathology - Sch of Med Cent