Physical activity and breast cancer risk: The European prospective investigation into cancer and nutrition

Lahmann, Petra H., Friedenreich, Christine, Jantine Schuit, A., Salvini, Simonetta, Allen, Naomi E., Key, Tim J., Khaw, Kay-Tee, Bingham, Sheila, Peeters, Petra H.M., Monninkhof, Evelyn, Bueno-de-Mesquita, H. Bas, Wirfält, Elisabet, Manjer, Jonas, Gonzales, Carlos A., Ardanaz, Eva, Amiano, Pilar, Quirós, José R., Navarro, Carmen, Martinez, Carmen, Berrino, Franco, Palli, Domenico, Tumino, Rosario, Panico, Salvatore, Vineis, Paolo, Trichopoulou, Antonia, Bamia, Christina, Trichopoulos, Dimitrios, Boeing, Heiner, Schulz, Mandy, Linseisen, Jakob, Chang-Claude, Jenny, Chapelon, Francoise Clavel, Fournier, Agnès, Boutron-Ruault, Marie-Christine, Tjønneland, Anne, Johnson, Nina Føns, Overvad, Kim, Kaaks, Rudolf and Riboli, Elio (2007) Physical activity and breast cancer risk: The European prospective investigation into cancer and nutrition. Epidemiology Biomarkers & Prevention, 16 1: 36-42. doi:10.1158/1055-9965.EPI-06-0582

Author Lahmann, Petra H.
Friedenreich, Christine
Jantine Schuit, A.
Salvini, Simonetta
Allen, Naomi E.
Key, Tim J.
Khaw, Kay-Tee
Bingham, Sheila
Peeters, Petra H.M.
Monninkhof, Evelyn
Bueno-de-Mesquita, H. Bas
Wirfält, Elisabet
Manjer, Jonas
Gonzales, Carlos A.
Ardanaz, Eva
Amiano, Pilar
Quirós, José R.
Navarro, Carmen
Martinez, Carmen
Berrino, Franco
Palli, Domenico
Tumino, Rosario
Panico, Salvatore
Vineis, Paolo
Trichopoulou, Antonia
Bamia, Christina
Trichopoulos, Dimitrios
Boeing, Heiner
Schulz, Mandy
Linseisen, Jakob
Chang-Claude, Jenny
Chapelon, Francoise Clavel
Fournier, Agnès
Boutron-Ruault, Marie-Christine
Tjønneland, Anne
Johnson, Nina Føns
Overvad, Kim
Kaaks, Rudolf
Riboli, Elio
Title Physical activity and breast cancer risk: The European prospective investigation into cancer and nutrition
Journal name Epidemiology Biomarkers & Prevention   Check publisher's open access policy
ISSN 1055-9965
Publication date 2007-01-01
Year available 2006
Sub-type Article (original research)
DOI 10.1158/1055-9965.EPI-06-0582
Open Access Status DOI
Volume 16
Issue 1
Start page 36
End page 42
Total pages 7
Place of publication Birmingham, AL, United States
Publisher American Association for Cancer Research
Language eng
Subject 1117 Public Health and Health Services
Formatted abstract
There is convincing evidence for a decreased risk of breast cancer with increased physical activity. Uncertainties remain, however, about the role of different types of physical activity on breast cancer risk and the potential effect modification for these associations. We used data from 218,169 premenopausal and postmenopausal women from nine European countries, ages 20 to 80 years at study entry into the European Prospective Investigation into Cancer and Nutrition. Hazard ratios (HR) from multivariate Cox regression models were calculated using metabolic equivalent value–based physical activity variables categorized in quartiles, adjusted for age, study center, education, body mass index, smoking, alcohol use, age at menarche, age at first pregnancy, parity, current oral contraceptive use, and hormone replacement therapy use. The physical activity assessment included recreational, household, and occupational activities. A total physical activity index was estimated based on cross-tabulation of these separate types of activity. During 6.4 years of follow-up, 3,423 incident invasive breast cancers were identified. Overall, increasing total physical activity was associated with a reduction in breast cancer risk among postmenopausal women (Ptrend = 0.06). Specifically, household activity was associated with a significantly reduced risk in postmenopausal (HR, 0.81; 95% confidence interval, 0.70-0.93, highest versus the lowest quartile; Ptrend = 0.001) and premenopausal (HR, 0.71; 95% confidence interval, 0.55-0.90, highest versus lowest quartile; Ptrend = 0.003) women. Occupational activity and recreational activity were not significantly related to breast cancer risk in both premenopausal and postmenopausal women. This study provides additional evidence for a protective effect of physical activity on breast cancer risk. (Cancer Epidemiol Biomarkers Prev 2007;16(1):36–42)
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 96 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 100 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 24 Mar 2009, 02:00:32 EST by Juliette Grosvenor on behalf of Library Corporate Services