Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women

Norat, T., Dossus, L., Rinaldi, S., Overvad, K., Grønbæk H., Tjønneland, A., Olsen, A., Clavel-Chapelon, F., Boutron-Ruault, M. C., Boeing, H., Lahmann, P. H., Linseisen, J., Nagel, G., Trichopoulou, A., Trichopoulos, D., Kalapothak, V., Sieri, S., Palli, D., Panico, S., Tumino, R., Sacerdote, C., Bueno-de-Mesquita, H. B., Peeters, P. H. M., van Gils, C. H., Agudo, A., Amiano, P., Ardanoz, E., Martinez, C., Quirós, R., Tormo, M. J., Bingham, S., Key, T. J., Allen, N. E., Ferrari, P., Slimani, N., Riboli, E. and Kaaks, R. (2007) Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women. European Journal of Clinical Nutrition, 61 1: 91-98. doi:10.1038/sj.ejcn.1602494

Author Norat, T.
Dossus, L.
Rinaldi, S.
Overvad, K.
Grønbæk H.
Tjønneland, A.
Olsen, A.
Clavel-Chapelon, F.
Boutron-Ruault, M. C.
Boeing, H.
Lahmann, P. H.
Linseisen, J.
Nagel, G.
Trichopoulou, A.
Trichopoulos, D.
Kalapothak, V.
Sieri, S.
Palli, D.
Panico, S.
Tumino, R.
Sacerdote, C.
Bueno-de-Mesquita, H. B.
Peeters, P. H. M.
van Gils, C. H.
Agudo, A.
Amiano, P.
Ardanoz, E.
Martinez, C.
Quirós, R.
Tormo, M. J.
Bingham, S.
Key, T. J.
Allen, N. E.
Ferrari, P.
Slimani, N.
Riboli, E.
Kaaks, R.
Title Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women
Journal name European Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 0954-3007
Publication date 2007-01-01
Sub-type Article (original research)
DOI 10.1038/sj.ejcn.1602494
Open Access Status Not yet assessed
Volume 61
Issue 1
Start page 91
End page 98
Total pages 8
Place of publication London
Publisher Nature Publishing
Language eng
Subject 1117 Public Health and Health Services
Abstract Objective: The aim of this study was to examine the relationship of diet with serum insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in women. Design: Cross-sectional study. Setting and subjects: The population are 2109 women who were control subjects in a case–control study of breast cancer nested in the European Prospective Investigation into Cancer and Nutrition. Control subjects were randomly chosen among risk sets consisting of female cohort members alive and free of cancer (except non-melanoma skin cancer) at the time of diagnosis of the index case. Matching criteria were age at enrolment, follow-up time, time of the day of blood collection and study centre. Diet was measured through validated questionnaires. Serum hormone concentrations were measured by enzyme-linked immunosorbent assays. The relationship between serum IGF-I, IGFBP-3, and intake of nutrients and foods was explored by linear regression in models adjusted for energy intake, age, body mass index, smoking, physical activity, centre and laboratory batch. Results: Serum IGF-I levels were positively related to protein intake (P trend<0.001), but not related to energy, fat or carbohydrate intake. Positive relationships were observed with the intake of milk (P trend=0.007), calcium (P trend<0.001), magnesium (P trend=0.003), phosphorus (P trend<0.001), potassium (P trend=0.002), vitamin B6 (P trend=0.03), vitamin B2 (P trend=0.001) and inverse relationships with vegetables (P trend=0.02) and beta-carotene (P trend=0.02). IGFBP-3 was not related with most of the nutrients and foods in this study. Conclusions: In this population, circulating IGF-I is modestly related with the intake of protein and minerals, and with milk and cheese, while IGFBP-3 does not appear to be related with diet.
Keyword insulin-like growth factor-I
insulin-like growth factor binding protein-3
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Guarantor: R Kaaks. Contributors: RK is the principal investigator of the study. TN and LD carried out data analysis. SR conducted the laboratory analyses. The writing team was integrated by TN, LD, SR and RK. All authors contributed to the collection of data, interpretation of results and to the writing of the paper.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
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