Kunjin replicon-based simian immunodeficiency virus gag vaccines

Anraku, Itaru, Mokhonov, Vladislav V., Rattanasena, Paweena, Mokhonova, Ekaterina I., Leung, Jason, Pijlman, Gorben, Cara, Andrea, Schroder, Wayne A., Khromykh, Alexander A. and Suhrbier, Andreas (2008) Kunjin replicon-based simian immunodeficiency virus gag vaccines. Vaccine, 26 26: 3268-3276. doi:10.1016/j.vaccine.2008.04.001


Author Anraku, Itaru
Mokhonov, Vladislav V.
Rattanasena, Paweena
Mokhonova, Ekaterina I.
Leung, Jason
Pijlman, Gorben
Cara, Andrea
Schroder, Wayne A.
Khromykh, Alexander A.
Suhrbier, Andreas
Title Kunjin replicon-based simian immunodeficiency virus gag vaccines
Formatted title
Kunjin replicon-based simian immunodeficiency virus gag vaccines
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-410X
Publication date 2008-06-19
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2008.04.001
Open Access Status Not yet assessed
Volume 26
Issue 26
Start page 3268
End page 3276
Total pages 9
Place of publication Kidlington, Oxford, UK
Publisher Elsevier
Language eng
Subject C1
060502 Infectious Agents
060506 Virology
110802 Medical Infection Agents (incl. Prions)
110804 Medical Virology
110309 Infectious Diseases
920109 Infectious Diseases
920412 Preventive Medicine
970111 Expanding Knowledge in the Medical and Health Sciences
Abstract An RNA-based, non-cytopathic replicon vector system, based on the flavivirus Kunjin, has shown considerable promise as a new vaccine delivery system. Here we describe the testing in mice of four different SIVmac239 gag vaccines delivered by Kunjin replicon virus-like-particles. The four vaccines encoded the wild type gag gene, an RNA-optimised gag gene, a codon-optimised gag gene and a modified gag-pol gene construct. The vaccines behaved quite differently for induction of effector memory and central memory responses, for mediation of protection, and with respect to insert stability, with the SIV gag-pol vaccine providing the optimal performance. These results illustrate that for an RNA-based vector the RNA sequence of the antigen can have profound and unforeseen consequences on vaccine behaviour.
Keyword SIV
Vaccine
Replicon
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 21 April 2008.

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
 
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Created: Mon, 23 Mar 2009, 23:28:49 EST by Jennifer Falknau on behalf of School of Chemistry & Molecular Biosciences