Biology and evolution of the endogenous koala retrovirus

Tarlinton, Rachael Eugenie, Meers, Joanne and Young, Paul R. (2008) Biology and evolution of the endogenous koala retrovirus. Cellular and Molecular Life Sciences, 65 21: 3413-3421. doi:10.1007/s00018-008-8499-y


Author Tarlinton, Rachael Eugenie
Meers, Joanne
Young, Paul R.
Title Biology and evolution of the endogenous koala retrovirus
Journal name Cellular and Molecular Life Sciences   Check publisher's open access policy
ISSN 1420-682X
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1007/s00018-008-8499-y
Open Access Status
Volume 65
Issue 21
Start page 3413
End page 3421
Total pages 9
Editor Jolles, P.
Place of publication Switzerland
Publisher Birkhaeuser Verlag AG
Language eng
Subject C1
060802 Animal Cell and Molecular Biology
970107 Expanding Knowledge in the Agricultural and Veterinary Sciences
Abstract Although endogenous retroviruses are ubiquitous features of all mammalian genomes, the process of initial germ line invasion and subsequent inactivation from a pathogenic element has not yet been observed in a wild species. Koala retrovirus (KoRV) provides a unique opportunity to study this process of endogenisation in action as it still appears to be spreading through the koala population. Ongoing expression of the endogenous sequence and consequent high levels of viraemia have been linked to neoplasia and immunosuppression in koalas. This apparently recent invader of the koala genome shares a remarkably close sequence relationship with the pathogenic exogenous Gibbon ape leukaemia virus (GALV), and comparative analyses of KoRV and GALVare helping to shed light on how retroviruses in general adapt to a relatively benign or at least less pathogenic existence within a new host genome. (Part of a Multi-author Review)
Keyword Retrovirus
koala
endogenous
gammaretrovirus
evolution
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Mon, 23 Mar 2009, 21:39:17 EST by Narelle Poole on behalf of School of Veterinary Science