Hydrodynamic modeling of traffic jams in intracellular transport in axons

Hooman, Kamel, Ejlali, A. and Abdel-Jawad, Madhat (2009) Hydrodynamic modeling of traffic jams in intracellular transport in axons. International Communications in Heat and Mass Transfer, 36 4: 329-334. doi:10.1016/j.icheatmasstransfer.2008.11.011

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Author Hooman, Kamel
Ejlali, A.
Abdel-Jawad, Madhat
Title Hydrodynamic modeling of traffic jams in intracellular transport in axons
Journal name International Communications in Heat and Mass Transfer   Check publisher's open access policy
ISSN 0735-1933
Publication date 2009-03-22
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.icheatmasstransfer.2008.11.011
Open Access Status File (Author Post-print)
Volume 36
Issue 4
Start page 329
End page 334
Total pages 6
Editor W.J. Minkowycz
Place of publication New York ; Oxford
Publisher Pergamon Press
Language eng
Subject 091306 Microelectromechanical Systems (MEMS)
091307 Numerical Modelling and Mechanical Characterisation
090302 Biomechanical Engineering
090399 Biomedical Engineering not elsewhere classified
Abstract Irregularities in intracellular traffic in axons caused by mutations of molecular motors may lead to “traffic jams”, which often result in swelling of axons causing such neurodegenerative diseases as Alzheimer’s disease and Down syndrome. Hence, it is of particular interest to mathematically model the formation of traffic jams in axons. This paper adopts the hydrodynamic continuity equations for intracellular transport of organelles as developed by Smith and Simmons [1] whereas the Kerner and Konhäuser [2] model for traffic jams in highway traffic is applied to predict the velocity field. It is observed that combination of the two sets of equations can comprehensively predict the traffic jams in axons without the need to any additional assumption or modification.
Keyword Numerical
Molecular motors
Motor-assisted transport
Axons and dendrites
Intracellular organelles
Traffic jams
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Mon, 23 Mar 2009, 20:30:15 EST by Kamel Hooman on behalf of School of Mechanical and Mining Engineering