Review: aspirin was effective for primary prevention of stroke in women and MI in men but increased major bleeding

Thompson, David R. (2006) Review: aspirin was effective for primary prevention of stroke in women and MI in men but increased major bleeding. Evidence-based nursing, 9 3: 76-76. doi:10.1136/ebn.9.3.76


Author Thompson, David R.
Title Review: aspirin was effective for primary prevention of stroke in women and MI in men but increased major bleeding
Journal name Evidence-based nursing   Check publisher's open access policy
ISSN 1367-6539
Publication date 2006-07-01
DOI 10.1136/ebn.9.3.76
Open Access Status DOI
Volume 9
Issue 3
Start page 76
End page 76
Total pages 1
Place of publication London
Publisher BMJ Publishing
Language eng
Subject 110299 Cardiovascular Medicine and Haematology not elsewhere classified
Abstract Data sources: Medline (1966 to March 2005), bibliographies of retrieved articles, and monitoring of major scientific meetings. Formula Study selection and assessment: randomised controlled trials (RCTs) that allocated participants to aspirin or a control group for primary prevention of CV disease and outcomes included CV mortality, myocardial infarction (MI), and stroke. Quality of individual studies was assessed based on allocation concealment, follow up, and objectivity of outcome assessments. 6 RCTs (51 342 women and 44 114 men, mean age 55–65 y) met the selection criteria. Aspirin dosage ranged from 100 mg every other day to 500 mg daily. Patient follow up was >95% in all trials, and duration of follow up ranged from 3.6 to 10.1 years. Formula Outcomes: composite endpoint of any major CV event (CV mortality, non-fatal MI, or non-fatal stroke), individual components of the composite endpoint, all cause mortality, and major bleeding. MAIN RESULTS: Both women and men in the aspirin
Keyword aspirin
platelet aggregation inhibitors
cardiovascular diseases
cerebrovascular accident

 
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Created: Mon, 23 Mar 2009, 19:03:34 EST by Ms Lynette Adams on behalf of School of Nursing, Midwifery and Social Work