Human Bocavirus: Passenger or pathogen in acute respiratory tract infection?

Schildgen, O., Muller, A., Allander, T., Mackay, Ian M., Volz, S., Kupfer, B. and Simon, A. (2008) Human Bocavirus: Passenger or pathogen in acute respiratory tract infection?. Clinical Microbiology Reviews, 21 2: 291-304. doi:10.1128/CMR.00030-07

Author Schildgen, O.
Muller, A.
Allander, T.
Mackay, Ian M.
Volz, S.
Kupfer, B.
Simon, A.
Title Human Bocavirus: Passenger or pathogen in acute respiratory tract infection?
Journal name Clinical Microbiology Reviews   Check publisher's open access policy
ISSN 0893-8512
Publication date 2008-04-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1128/CMR.00030-07
Open Access Status DOI
Volume 21
Issue 2
Start page 291
End page 304
Total pages 14
Editor Nachamkin I.
Place of publication The United States of America
Publisher American Society for Microbiology
Language eng
Subject 060506 Virology
060502 Infectious Agents
060309 Phylogeny and Comparative Analysis
110804 Medical Virology
920109 Infectious Diseases
920115 Respiratory System and Diseases (incl. Asthma)
920501 Child Health
920203 Diagnostic Methods
Abstract Summary: Human bocavirus (HBoV) is a newly identified virus tentatively assigned to the family Parvoviridae, subfamily Parvovirinae, genus Bocavirus. HBoV was first described in 2005 and has since been detected in respiratory tract secretions worldwide. Herein we review the literature on HBoV and discuss the biology and potential clinical impact of this virus. Most studies have been PCR based and performed on patients with acute respiratory symptoms, from whom HBoV was detected in 2 to 19% of the samples. HBoV-positive samples have been derived mainly from infants and young children. HBoV DNA has also been detected in the blood of patients with respiratory tract infection and in fecal samples of patients with diarrhea with or without concomitant respiratory symptoms. A characteristic feature of HBoV studies is the high frequency of coinciding detections, or codetections, with other viruses. Available data nevertheless indicate a statistical association between HBoV and acute respiratory tract disease. We present a model incorporating these somewhat contradictory findings and suggest that primary HBoV infection causes respiratory tract symptoms which can be followed by prolonged low-level virus shedding in the respiratory tract. Detection of the virus in this phase will be facilitated by other infections, either simply via increased sample cell count or via reactivation of HBoV, leading to an increased detection frequency of HBoV during other virus infections. We conclude that the majority of available HBoV studies are limited by the sole use of PCR diagnostics on respiratory tract secretions, addressing virus prevalence but not disease association. The ability to detect primary infection through the development of improved diagnostic methods will be of great importance for future studies seeking to assign a role for HBoV in causing respiratory illnesses.
Keyword Human Bocavirus
Respiratory infection
clinical impact
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: 2009 Higher Education Research Data Collection
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Citation counts: TR Web of Science Citation Count  Cited 176 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 191 times in Scopus Article | Citations
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Created: Sat, 21 Mar 2009, 00:02:20 EST by Lesley Arnicar on behalf of Clinical Medical Virology Centre