Homocysteine concentrations lowered following dietary intervention in an Aboriginal community.

Rowley, K. G., Lee, A. J., Yarmirr, D. and O'Dea, K. (2003) Homocysteine concentrations lowered following dietary intervention in an Aboriginal community.. Asia Pacific Journal of Clinical Nutrition, 12 1: 92-95.

Author Rowley, K. G.
Lee, A. J.
Yarmirr, D.
O'Dea, K.
Title Homocysteine concentrations lowered following dietary intervention in an Aboriginal community.
Journal name Asia Pacific Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 0964-7058
Publication date 2003-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 12
Issue 1
Start page 92
End page 95
Total pages 4
Place of publication Clayton, VIC
Publisher Blackwell Science Asia
Language eng
Subject 111104 Public Nutrition Intervention
Abstract Low circulating folate concentrations lead to elevations of plasma homocysteine. Even mild elevations of plasma homocysteine are associated with significantly increased risk of cardiovascular disease (CVD). Available evidence suggests that poor nutrition contributes to excessive premature CVD mortality in Australian Aboriginal people. The aim of the present study was to examine the effect of a nutrition intervention program conducted in an Aboriginal community on plasma homocysteine concentrations in a community-based cohort. From 1989, a health and nutrition project was developed, implemented and evaluated with the people of a remote Aboriginal community. Plasma homocysteine concentrations were measured in a community-based cohort of 14 men and 21 women screened at baseline, 6 months and 12 months. From baseline to 6 months there was a fall in mean plasma homocysteine of over 2 I molll (P = 0.006) but no further change thereafter (P = 0.433). These changes were associated with a significant increase in red cell folate concentration from baseline to 6 months (P < 0.001) and a further increase from 6 to 12 months (P < 0.00 I). In multiple regression analysis, change in homocysteine concentration from baseline to 6 months was predicted by change in red cell folate (P = 0.002) and baseline homocysteine (P < 0.001) concentrations, but not by age. gender or baseline red cell folate concentration. We conclude that modest improvements in dietary quality among populations with poor nutrition (and limited disposable income) can lead to reductions in CVD risk.
Keyword Homocysteine
Community-based Intervention
Aboriginal people
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Journal of the Asia Pacific Clinical Nutrition Society; and an organ of the Australasian Clinical Nutrition Society, the Asia Pacific Public Health Nutrition Association and the Nutrition Society of Australia.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Human Movement and Nutrition Sciences Publications
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