Maternal anxiety at amniocentesis and plasma cortisol

Sarkar, P., Bergman, K., Fisk, N. M. and Glover, V. (2006) Maternal anxiety at amniocentesis and plasma cortisol. Prenatal Diagnosis, 26 6: 505-509. doi:10.1002/pd.1444


Author Sarkar, P.
Bergman, K.
Fisk, N. M.
Glover, V.
Title Maternal anxiety at amniocentesis and plasma cortisol
Journal name Prenatal Diagnosis   Check publisher's open access policy
ISSN 1097-3851; 0197-3851
Publication date 2006-06-01
Year available 2006
Sub-type Article (original research)
DOI 10.1002/pd.1444
Open Access Status Not yet assessed
Volume 26
Issue 6
Start page 505
End page 509
Total pages 5
Editor D. W. Bianchi
Place of publication Chichester, U.K.
Publisher Wiley
Language eng
Subject 111401 Foetal Development and Medicine
111402 Obstetrics and Gynaecology
1114 Paediatrics and Reproductive Medicine
Abstract Objectives To assess whether anticipation of amniocentesis is linked with maternal anxiety, and whether this anxiety is associated with increased maternal plasma cortisol.
Formatted abstract
Objectives: To assess whether anticipation of amniocentesis is linked with maternal anxiety, and whether this anxiety is associated with increased maternal plasma cortisol.
Methods: Two hundred and fifty-four women awaiting a morning amniocentesis for karyotyping (gestation range 15-37 weeks, median 17 weeks) completed Spielberger state and trait anxiety inventory (STAI) questionnaires, and provided blood samples immediately before the procedure for cortisol assay. Six hundred and five women at mean gestation of 20 weeks, attending the same hospital for routine ultrasound but not for amniocentesis, also completed Spielberger STAI questionnaires and served as a comparison group for the anxiety ratings.
Results: Mean state and trait anxiety scores (± SD) in the comparison group of 605 women at mean gestation of 20 weeks were 36.1 ± 10.2 (range 20-70) and 35.6 ± 8.9 (range 20-73), respectively. The mean state anxiety score (±SD) of 49.8 ± 14.0 (range 20-77) of the amniocentesis group was considerably higher than the comparison group (p < 0.001), although the mean trait anxiety score in the amniocentesis group was similar at 36.4 ± 8.6 (range 21-60). The state, but not trait, anxiety correlated with plasma cortisol (r = 0.176, p = 0.005). Maternal cortisol in the amniocentesis group increased with gestational age (r = 0.310, p < 0.001), whereas state anxiety scores showed no significant change with increase in gestational age (r = - 0.042, ns). Multivariate analysis demonstrated that maternal state anxiety was positively correlated with plasma cortisol independent of gestation and time of collection.
Conclusion: Women awaiting amniocentesis experience a high state anxiety associated with modestly increased plasma cortisol.
Copyright © 2010 John Wiley & Sons, Ltd.

Keyword Amniocentesis
Anxiety
Cortisol
HPA axis
Pregnancy
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Fri, 20 Mar 2009, 23:25:19 EST by Mary-Anne Marrington on behalf of Faculty Of Health Sciences