Determinants of flow along arterio-arterial anastomoses in monochorionic placentae by dynamic computer modelling of chorionic plate vasculature

Denbow, Mark L., Talbert, David and Fisk, Nicholas M. (2006) Determinants of flow along arterio-arterial anastomoses in monochorionic placentae by dynamic computer modelling of chorionic plate vasculature. Prenatal Diagnosis, 26 5: 433-442. doi:10.1002/pd.1432


Author Denbow, Mark L.
Talbert, David
Fisk, Nicholas M.
Title Determinants of flow along arterio-arterial anastomoses in monochorionic placentae by dynamic computer modelling of chorionic plate vasculature
Journal name Prenatal Diagnosis   Check publisher's open access policy
ISSN 1097-3851; 0197-3851
Publication date 2006-05-01
Year available 2006
Sub-type Article (original research)
DOI 10.1002/pd.1432
Open Access Status Not yet assessed
Volume 26
Issue 5
Start page 433
End page 442
Total pages 10
Editor D. W. Bianchi
Place of publication Chichester, U.K.
Publisher Wiley
Language eng
Subject 111401 Foetal Development and Medicine
111402 Obstetrics and Gynaecology
1114 Paediatrics and Reproductive Medicine
Abstract Objectives To investigate anatomical and physiological determinants of inter-fetal transfusion along arterio-arterial (AA) anastomoses in monochorionic placentae.
Formatted abstract
Objectives: To investigate anatomical and physiological determinants of inter-fetal transfusion along arterio-arterial (AA) anastomoses in monochorionic placentae.
Methods: A computer model of chorionic arterial vasculature was constructed in QuickBASIC using data collected from experimentation and the published literature. After validating the model, the influence of various physiological and anatomical variables on anastomotic flow rates was examined.
Results: AA anastomotic flow rates were significantly related to changes in fetal mean arterial pressure (p < 0.0001) and heart rate (p < 0.0005). AA flow rates were also related to the imbalance in number of arterio-venous (AV) anastomoses, to placental territory share, and to the branch number of the AA anastomosis (AAAs) from the chorionic arterial tree.
Conclusions: Net blood flow and direction along AA anastomoses are influenced by fetal cardiac output, by the presence of compensatory AV anastomoses, and by the branch number of the chorionic arteries connected by the anastomosis. This study provides insight into the determinants of chronic transfusional imbalance as well as acute inter-fetal transfusion.
Copyright © 2010 John Wiley & Sons, Ltd.

Keyword Monochorionic placentation
Arterio-arterial anastomoses
Twin-twin transfusion syndrome
Physiological modelling
Doppler
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Fri, 20 Mar 2009, 23:12:57 EST by Mary-Anne Marrington on behalf of Faculty Of Health Sciences