Investigation of the relationship between smoking and appendicitis in Australian twins

Oldmeadow, Chris, Wood, Ian, Mengersen, Kerrie, Visscher, Peter M., Martin, Nicholas G. and Duffy, David L. (2008) Investigation of the relationship between smoking and appendicitis in Australian twins. Annals of Epidemiology, 18 8: 631-636. doi:10.1016/j.annepidem.2008.04.004

Author Oldmeadow, Chris
Wood, Ian
Mengersen, Kerrie
Visscher, Peter M.
Martin, Nicholas G.
Duffy, David L.
Title Investigation of the relationship between smoking and appendicitis in Australian twins
Journal name Annals of Epidemiology   Check publisher's open access policy
ISSN 1047-2797
Publication date 2008-08-01
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.annepidem.2008.04.004
Open Access Status Not yet assessed
Volume 18
Issue 8
Start page 631
End page 636
Total pages 6
Editor R. Rothenberg
Place of publication United States
Publisher Elsevier Inc.
Language eng
Subject C1
970101 Expanding Knowledge in the Mathematical Sciences
010401 Applied Statistics
111706 Epidemiology
Abstract Purpose Appendicitis is an inflammation of the appendix, the etiology of which is still poorly understood. Previous studies have shown an increased risk for cigarette smokers but no accounts for the timing of exposure to smoking relative to appendectomy were made. Methods Based on questionnaire data, both cohort and co-twin case-control analyses were conducted to assess the effect of active cigarette smoking on appendectomy in 3808 Australian twin pairs. Smoking status was defined as a time-dependent covariate to account for differences in timing of smoking initiation and onset of appendicitis. Results The questionnaire had a 65% pairwise response rate. After controlling for sex, age, and year of birth, appendectomy risk in current smokers was statistically significantly increased by 65% relative to never-smokers. This was largely unchanged by the duration or intensity of smoking and was not affected by socioeconomic status or father's occupation. The effect was stronger in females. Among former smokers, increased time since quitting significantly reduced the odds ratio of appendectomy by 15% for every year since quitting. Conclusion After adjustment for age and other confounders, there was an increase in risk of appendectomy among current smokers relative to never-smokers, particularly in females. This study adds to the body of knowledge on the effects of tobacco smoking on the gastrointestinal tract. Abbreviations: UC, ulcerative colitis; ATR, Australian Twin Registry; OR, odds ratio; RR, relative risk; MZ, monozygous twin; DZ, dizygous twin; CI, confidence interval
Keyword Public, Environmental & Occupational Health
Public, Environmental & Occupational Health
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 20 Mar 2009, 23:09:57 EST by Marie Grove on behalf of School of Mathematics & Physics